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Claims for Patent: 5,037,845

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Claims for Patent: 5,037,845

Title: Indole derivative
Abstract:A compound of formula (I) ##STR1## and its physiologically acceptable salts and solvates are described as useful in treating and/or preventing pain resulting from dilatation of the cranial vasculature in particular migraine. The compound (I) may be prepared, for example, by cyclizing a compound of formula (II) ##STR2##
Inventor(s): Oxford; Alexander W. (Royston, GB2)
Assignee: Glaxo Group Limited (GB2)
Application Number:07/317,682
Patent Claims: 1. A compound of formula (I): ##STR18## and its physiologically acceptable salts and solvates.

2. A compound according to claim 1, wherein the physiologically acceptable salt is an acid addition salt formed with an organic or inorganic acid.

3. A compound according to claim 2, wherein the physiologically acceptable salt is a hydrochloride, hydrobromide, sulphate, nitrate, phosphate, formate, mesylate, citrate, benzoate, fumarate, maleate or succinate.

4. A compound according to claim 3, wherein the physiologically acceptable salt is the 1:1 succinate.

5. A pharmaceutical composition comprising as active ingredient an effective amount of the compound of formula (I) as defined in claim 1 or a physiologically acceptable salt or solvate thereof, together with one or more pharmaceutically acceptable carriers or excipients for use in the treatment or prevention of pain resulting from dilatation of the cranial vasculature.

6. A pharmaceutical composition according to claim 5 which is formulated for oral administration to humans.

7. A pharmaceutical composition according to claim 6, which is formulated in unit dosage form comprising 0.1 mg to 100 mg of active ingredient.

8. A pharmaceutical composition according to claim 7, which is formulated in unit dosage form comprising 0.5 mg to 50 mg of active ingredient.

9. A pharmaceutical composition according to claim 8, which is formulated in unit dosage form comprising 2 mg to 40 mg of active ingredient.

10. A method of treating a human being susceptible to or suffering from migraine which comprises administering an effective amount of a compound of formula (I) as defined in claim 1 or a physiologically acceptable salt or solvate thereof.

11. A method of treating a human being susceptible to or suffering from migraine which comprises administering a pharmaceutical composition according to claim 5.

12. A method of treating a human being susceptible to or suffering from migraine which comprises administering by the oral route a pharmaceutical composition according to claim 6.
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