|Title:|| Method of treating autoimmune diseases comprising administration of psoralen dosage forms|
|Abstract:||A method of treating leukocyte mediated autoimmune and skin diseases using psoralen reagent composition comprising sterile aqueous solutions suitable for extracorporeal administration to blood from a subject being treated by ultraviolet-A photophoresis.|
|Inventor(s):|| Bachynsky; Maria O. (Nutley, NJ), Infeld; Martin H. (Upper Montclair, NJ), Margolis; Richard J. (Wayne, NJ), Perla; Dennis A. (Wayne, NJ) |
|Assignee:|| Hoffmann-La Roche Inc. (Nutley, NJ) |
1. A method for the therapy of leukocyte mediated diseases comprising extracorporeal administration to the blood of a subject undergoing ultraviolet-A photophoresis prior to reinfusion
of the blood into said subject a composition comprising a sterile aqueous solution of about 0.005 mg/ml to about 1 mg/ml of a psoralen, ethyl alcohol, propylene glycol and water, said composition having a pH from about 2.0 to about 5.5.
2. The method of claim 1 wherein the leukocyte mediated condition is selected from the group consisting of Scleroderma, Systemic Lupus Erythematosis (SLE) Psoriasis, Pemphigus, Psoriatic Arthritis, Atopic Dermatitis, Rheumatoid Arthritis,
3. The method of claim 1 wherein the psoralen is 8-MOP.
4. The method of claim 3 wherein the 8-MOP is administered to the patient's blood just after it is withdrawn from the patient and prior to its separation into leukocyte rich and leukocyte poor fractions.