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|Title:||Method of treating autoimmune diseases comprising administration of psoralen dosage forms|
|Abstract:||A method of treating leukocyte mediated autoimmune and skin diseases using psoralen reagent composition comprising sterile aqueous solutions suitable for extracorporeal administration to blood from a subject being treated by ultraviolet-A photophoresis.|
|Inventor(s):||Bachynsky; Maria O. (Nutley, NJ), Infeld; Martin H. (Upper Montclair, NJ), Margolis; Richard J. (Wayne, NJ), Perla; Dennis A. (Wayne, NJ)|
|Assignee:||Hoffmann-La Roche Inc. (Nutley, NJ)|
1. A method for the therapy of leukocyte mediated diseases comprising extracorporeal administration to the blood of a subject undergoing ultraviolet-A photophoresis prior to reinfusion
of the blood into said subject a composition comprising a sterile aqueous solution of about 0.005 mg/ml to about 1 mg/ml of a psoralen, ethyl alcohol, propylene glycol and water, said composition having a pH from about 2.0 to about 5.5.
2. The method of claim 1 wherein the leukocyte mediated condition is selected from the group consisting of Scleroderma, Systemic Lupus Erythematosis (SLE) Psoriasis, Pemphigus, Psoriatic Arthritis, Atopic Dermatitis, Rheumatoid Arthritis, Multiple Sclerosis.
3. The method of claim 1 wherein the psoralen is 8-MOP.
4. The method of claim 3 wherein the 8-MOP is administered to the patient's blood just after it is withdrawn from the patient and prior to its separation into leukocyte rich and leukocyte poor fractions.
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