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Claims for Patent: 5,024,843

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Claims for Patent: 5,024,843

Title: Oral hypoglycemic glipizide granulation
Abstract:A dosage form is disclosed comprising the antidiabetic drug glipizide for administering to a patient in need of glipizide therapy.
Inventor(s): Kuczynski; Anthony L. (Palo Alto, CA), Ayer; Atul D. (Palo Alto, CA), Wong; Patrick S.-L. (Palo Alto, CA)
Assignee: ALZA Corporation (Palo Alto, CA)
Application Number:07/402,314
Patent Claims: 1. A pharmaceutical granulation comprising granules of 2 mg to 50 mg of substantially aqueous insoluble glipizide, from 100 mg to 320 mg of a polyethylene oxide having a 80,000 to 350,000 molecular weight, and from 5 mg to 50 mg of a hydroxypropylmethylcellulose having a 9,200 to 2,000 molecular weight, which granules are useful for manufacturing an osmotic dosage form for dispensing the glipizide for up to 22 hours when the dosage form is in gastrointestinal tract of a patient.

2. A pharmaceutical granulation comprising granules of 2 mg to 25 mg of substantially aqueous insoluble glipizide, from 40 mg to 70 mg of a polyvinylpyrrolidone having a 30,000 to 70,000 molecular weight, and from 100 to 150 mg of a hydroxypropylcellulose having a 40,000 to 80,000 molecular weight, and wherein the granules are useful for manufacturing an osmotic dosage form for dispensing the glipizide for up to 22 hours when the dosage form is in the gastrointestinal tract of a patient.
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Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

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