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|Title:||Pharmaceutically useful polymorphic modification of buspirone|
|Abstract:||"Buspirone hydrochloride can exist in two polymorphic forms and the newly discoverd lower melting form, which is thermodynamically favored at pharmaceutically relevant temperatures, offers advantage in manufacture of buspirone pharmaceutical compositions".|
|Inventor(s):||Simms, deceased; Jack C. (late of Elberfeld, IN)|
|Assignee:||Bristol-Myers Squibb Co. (New York, NY)|
1. The lower melting polymorphic crystalline form of buspirone hydrochloride, characterized by a melting point of about 188.degree. C., in pharmaceutically purified form.
2. A method for treating anxiety in a patient in need of such treatment comprising administering an amount of the lower melting buspirone hydrochloride polymorph in pharmaceutically purified form of claim 1 effective for such treatment.
3. A pharmaceutical composition comprising the lower melting buspirone hydrochloride polymorph in pharmaceutically purified form of claim 1 and a carrier.
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