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Generated: September 21, 2017

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Title: Selective antibacterial agent against campytobacter
Abstract:The compound represented by the formula; ##STR1## [wherein R.sup.1 stands for hydrogen, methoxy or trifluoromethyl; R.sup.2 and R.sup.3, being the same or different from each other, stand for hydrogen or methyl; R.sup.4 stands for optionally substituted hydrocarbon residue; and n denotes 0 or 1] or a salt thereof show excellent antibacterial activities, against the genus Campylobacter, especially against Campylobacter pylori, and they are used for preventing or treating infectious diseases caused by the said bacteria.
Inventor(s): Iwahi; Tomoyuki (Suita, JP), Satoh; Hiroshi (Suita, JP)
Assignee: Takeda Chemical Industries, Ltd. (Osaka, JP)
Application Number:07/478,405
Patent Claims: 1. A method for combatting infectious diseases caused by the genus campylobater which comprises administering to a mammal in need thereof an antibiotially-effective amount of a compound of the formula ##STR3## wherein R.sup.1 stands for hydrogen, methoxy or triflouromethyl; R.sup.2 and R.sup.3, being the same or different from each other, stand for hydrogen or methyl; and R.sup.4 stands for optionally substituted hydrocarbon residue and n denotes 0 or 1, or a pharmacologically acceptable salt thereof.

2. A method according to claim 1, wherein R.sup.1 is hydrogen.

3. A method according to claim 1, wherein R.sup.3 is hydrogen.

4. A method according to claim 1, wherein R.sup.4 is fluorinated alkyl group.

5. A method according to claim 1, wherein R.sup.4 is fluorinated alkyl group.

6. A method according to claim 1, wherein R.sup.1 is fluorinated alkyl group.

7. A method according to claim 1, wherein the compound is 2-{3-methyl-4-(2,2,2-trifluoroethoxy)pyrid-2-yl}methylsulfinylbenzimidazol e.

8. A method according to claim l, wherein the compound is 2-{3-methyl-4-(2,2,2-trifluoroethoxy)pyrid-2-yl}methylthiobenzimidazole.

9. A method according to claim 1, wherein the compound is 2-{3-methyl-4-(2,2,3,3,3-pentafluoropropoxy)pyrid-2-yl}methylsulfinylbenzi midazole.

10. A method according to claim 1, wherein the compound is 2-{3-methyl-4-(2,2,3,3,3-pentafluoropropoxy)pyrid-2-yl}methylthiobenzimida zole.

11. A method according to claim 1, wherein the compound is 2-{3-methyl-4-(2,2,3,3-tetrafluoropropoxy)pyrid-2-yl}methylsulfinylbenzimi dazole.

12. A method according to claim 1, wherein the compound is 2-{3-methyl-4-(2,2,3,3-tetrafluoropropoxy)pyrid-2-yl}methylthiobenzimidazo le.

13. A method according to claim 1, wherein the compound is 2-{3-methyl-4-(2,2,3,3,4,4-hexafluorobutyloxy)pyrid-2-yl}methylsulfinylben zimidazole.

14. A method according to claim 1, wherein the compound is 2-{3-methyl-4-(2,2,3,3,4,4-hexafluorobutyloxy)pyrid-2-yl}methylthiobenzimi dazole.

15. A method according to claim 1, wherein the compound is 2-(3,5-dimethyl-4-methoxypyrid-2-yl)methylsulfinyl-5-methoxybenzimidazole.
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Julphar
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