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Claims for Patent: 4,988,827

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Claims for Patent: 4,988,827

Title: Ether isonitriles and radiolabeled complexes thereof
Abstract:Ether-substituted isonitriles, Tc99m complexes thereof, and processes for myocardial tissue radioimaging using the Tc99m complexes.
Inventor(s): Bergstein; Paul L. (Norwood, MA), Subramanyam; Vinayakam (Wilmington, DE)
Assignee: E. I. Du Pont de Nemours and Company (Wilmington, DE)
Application Number:07/056,003
Patent Claims: 1. A compound which is an ether-substituted isonitrile of the formula: ##STR12## wherein A is a straight or branched chain alkylene group, and

R and R.sup.1 each independently is a straight or branched chain alkyl group or taken together are a straight or branched chain alkylene group,

provided that

(1) the total number of carbon atoms in A plus R in formula (I) is 4 to 6, provided further that when the total number of carbon atoms is 6, then the carbon atom alpha to the isonitrile group is a quaternary carbon, and still further provided that A is not (CH.sub.2).sub.3, and

(2) the total number of carbon atoms in A plus R plus R.sup.1 in formula (Ia) is 4 to 9.

2. The compound of claim I in sterile, non-pyrogenic form.

3. The compound of claim 1 wherein the ether-substituted isonitrile is of formula (Ia) and the total number of carbon atoms in A plus R plus R.sup.1 is 4 to 7.

4. The compound of claim 3 wherein the ether substituted isonitrile is ##STR13##

5. The compound of claim 3 in sterile, non-pyrogenic form.

6. The compound of claim 1 wherein the ether-substituted isonitrile is of formula (I).

7. The compound of claim 6 wherein the ether-substituted isonitrile is CNCH.sub.2 C(CH.sub.3).sub.2 OCH.sub.3.

8. The compound of claim 6 wherein the ether-substituted isonitrile is CNC(CH.sub.3).sub.2 CH.sub.2 OCH.sub.3.

9. The compound of claim 2 wherein the ether-substituted isonitrile is CNCH(CH.sub.3)CH.sub.2 OCH.sub.3.

10. The compound of claim 6 wherein the ether-substituted isonitrile is CNCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3.

11. The compound of claim 6 wherein the ether-substituted isonitrile is CNCH.sub.2 CH(CH.sub.3)OCH.sub.3.

12. The compound of claim 6 wherein the ether-substituted isonitrile is CNCH.sub.2 CH(CH.sub.3)OCH.sub.2 CH.sub.3.

13. The compound of claim 6 wherein the ether-substituted isonitrile is CNCH(CH.sub.3)CH(CH.sub.3)OCH.sub.3.

14. The compound of claim 6 wherein the ether-substituted isonitrile is CNCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.3.

15. The compound of claim 6 wherein the ether-substituted isonitrile is CNCH.sub.2 CH.sub.2 CH(CH.sub.3)OCH.sub.3.

16. The compound of claim 6 wherein the ether-substituted isonitrile is CNC(CH.sub.3).sub.2 OCH.sub.2 CH.sub.3.

17. The compound of claim 6 wherein the ether-substituted isonitrile is CNC(CH.sub.3).sub.2 OCH.sub.3.

18. The compound of claim 6 wherein the ether-substituted isonitrile is CN(CH.sub.2).sub.2 OCH(CH.sub.3).sub.2.

19. The compound of claim 6 wherein the ether-substituted isonitrile is CN(CH.sub.2).sub.2 OCH.sub.2 CH.sub.3.

20. The compound of claim 6 wherein the ether-substituted isonitrile is CNCH.sub.2 CH(CH.sub.2 CH.sub.3)OCH.sub.3.

21. The compound of claim 6 wherein the ether-substituted isonitrile is CNCH(CH.sub.2 CH.sub.3)CH.sub.2 OCH.sub.3.

22. The compound of claim 6 wherein the ether-substituted isonitrile is CNCHCH.sub.3 OCH(CH.sub.3).sub.2.

23. The compound of claim 6 wherein the ether-substituted isonitrile is CNCH(CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.3.

24. The compound of claim 6 wherein the ether-substituted isonitrile is CNC(CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.3.

25. The compound of claim 6 in sterile, non-pyrogenic form.

26. The compound of any of claims 8 and 9 through 24 in sterile, non-pyrogenic form.
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