Claims for Patent: 4,988,827

Summary for Patent: 4,988,827

Title:	Ether isonitriles and radiolabeled complexes thereof
Abstract:	Ether-substituted isonitriles, Tc99m complexes thereof, and processes for myocardial tissue radioimaging using the Tc99m complexes.
Inventor(s):	Bergstein; Paul L. (Norwood, MA), Subramanyam; Vinayakam (Wilmington, DE)
Assignee:	E. I. Du Pont de Nemours and Company (Wilmington, DE)
Application Number:	07/056,003
Patent Claims:	1. A compound which is an ether-substituted isonitrile of the formula: ##STR12## wherein A is a straight or branched chain alkylene group, and R and R.sup.1 each independently is a straight or branched chain alkyl group or taken together are a straight or branched chain alkylene group, provided that (1) the total number of carbon atoms in A plus R in formula (I) is 4 to 6, provided further that when the total number of carbon atoms is 6, then the carbon atom alpha to the isonitrile group is a quaternary carbon, and still further provided that A is not (CH.sub.2).sub.3, and (2) the total number of carbon atoms in A plus R plus R.sup.1 in formula (Ia) is 4 to 9. 2. The compound of claim I in sterile, non-pyrogenic form. 3. The compound of claim 1 wherein the ether-substituted isonitrile is of formula (Ia) and the total number of carbon atoms in A plus R plus R.sup.1 is 4 to 7. 4. The compound of claim 3 wherein the ether substituted isonitrile is ##STR13## 5. The compound of claim 3 in sterile, non-pyrogenic form. 6. The compound of claim 1 wherein the ether-substituted isonitrile is of formula (I). 7. The compound of claim 6 wherein the ether-substituted isonitrile is CNCH.sub.2 C(CH.sub.3).sub.2 OCH.sub.3. 8. The compound of claim 6 wherein the ether-substituted isonitrile is CNC(CH.sub.3).sub.2 CH.sub.2 OCH.sub.3. 9. The compound of claim 2 wherein the ether-substituted isonitrile is CNCH(CH.sub.3)CH.sub.2 OCH.sub.3. 10. The compound of claim 6 wherein the ether-substituted isonitrile is CNCH(CH.sub.3)CH.sub.2 OCH.sub.2 CH.sub.3. 11. The compound of claim 6 wherein the ether-substituted isonitrile is CNCH.sub.2 CH(CH.sub.3)OCH.sub.3. 12. The compound of claim 6 wherein the ether-substituted isonitrile is CNCH.sub.2 CH(CH.sub.3)OCH.sub.2 CH.sub.3. 13. The compound of claim 6 wherein the ether-substituted isonitrile is CNCH(CH.sub.3)CH(CH.sub.3)OCH.sub.3. 14. The compound of claim 6 wherein the ether-substituted isonitrile is CNCH.sub.2 CH(CH.sub.3)CH.sub.2 OCH.sub.3. 15. The compound of claim 6 wherein the ether-substituted isonitrile is CNCH.sub.2 CH.sub.2 CH(CH.sub.3)OCH.sub.3. 16. The compound of claim 6 wherein the ether-substituted isonitrile is CNC(CH.sub.3).sub.2 OCH.sub.2 CH.sub.3. 17. The compound of claim 6 wherein the ether-substituted isonitrile is CNC(CH.sub.3).sub.2 OCH.sub.3. 18. The compound of claim 6 wherein the ether-substituted isonitrile is CN(CH.sub.2).sub.2 OCH(CH.sub.3).sub.2. 19. The compound of claim 6 wherein the ether-substituted isonitrile is CN(CH.sub.2).sub.2 OCH.sub.2 CH.sub.3. 20. The compound of claim 6 wherein the ether-substituted isonitrile is CNCH.sub.2 CH(CH.sub.2 CH.sub.3)OCH.sub.3. 21. The compound of claim 6 wherein the ether-substituted isonitrile is CNCH(CH.sub.2 CH.sub.3)CH.sub.2 OCH.sub.3. 22. The compound of claim 6 wherein the ether-substituted isonitrile is CNCHCH.sub.3 OCH(CH.sub.3).sub.2. 23. The compound of claim 6 wherein the ether-substituted isonitrile is CNCH(CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.3. 24. The compound of claim 6 wherein the ether-substituted isonitrile is CNC(CH.sub.3)CH.sub.2 CH.sub.2 OCH.sub.3. 25. The compound of claim 6 in sterile, non-pyrogenic form. 26. The compound of any of claims 8 and 9 through 24 in sterile, non-pyrogenic form.