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Claims for Patent: 4,983,598

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Claims for Patent: 4,983,598

Title: Pharmaceutical composition containing diltiazem and angiotensin-converting enzyme inhibitor
Abstract:Compositions of diltiazem and angiotensin-converting enzyme inhibitor useful for the treatment of hypertension, cardiac insufficiency and coronary insufficiency.
Inventor(s): Cavero; Icilio (Creteil, FR), Elkik; Francois (Paris, FR), Hicks; Peter (Cachan, FR), Muller; Jean-Claude (Morsang S/Orge, FR)
Assignee: Synthelabo (Paris, FR)
Application Number:07/195,151
Patent Claims: 1. A pharmaceutical composition containing a combination of 10-360 mg of diltiazem and 1-100 mg of an angiotensin-converting enzyme inhibitor, enalapril useful for the treatment of hypertension, cardiac insufficiency, and coronary insufficiency, such that the anti-hypertensive effect observed upon combined administration of diltiazem and said angiotensin-converting enzyme inhibitor is greater than the sum of the individual anti-hypertensive effects observed upon the separate administration of diltiazem and said angiotensin-converting enzyme inhibitor alone.

2. A method for treatment of hypertension, cardiac insufficiency or coronary insufficiency comprising administering to a subject suffering therefrom a pharmaceutical composition containing a combination of 10 to 360 mg of diltiazem and 1 to 100 mg of an angiotensin-converting enzyme inhibitor, enalapril, such that the anti-hypertenive effect observed upon administration of the combined administration of diltiazem and said angiotensin-converting enzyme inhibitor is greater than the sum of the individual anti-hypertensive effects observed upon the separate administration of diltiazem and said angiotensin-converting enzyme inhibitor alone.
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