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|Title:||Aqueous steroid formulations for nasal administration|
|Abstract:||A non-stinging aqueous anti-inflammatory steroid formulation suitable for intranasal administration comprises: an anti-inflammatory steroid in an amount between about 0.01% and about 0.05% (w/v); propylene glycol in an amount between about 2% and about 10% (w/v); PEG 400 in an amount between about 10% and about 25% (w/v); polysorbate 20 in an amount between about 1% and about 4% (w/v); an effective amount of a preservative; an effective amount of a stabilizer; an effective amount of an antioxidant; water; and pH buffering agent sufficient to adjust the pH of the resulting solution to between about 3.5 and about 7.|
|Inventor(s):||Benjamin; Eric (Dublin, OH), Anik; Shabbir (Mountain View, CA), Lin; Ya-Yun T. (Cupertino, CA)|
|Assignee:||Syntex (U.S.A.) Inc. (Palo Alto, CA)|
|Patent Claims:||1. A stable, effectively preservable, substantially non-stinging aqueous anti-inflammatory steroid formulation suitable for intranasal administration, which formulation comprises:|
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