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Claims for Patent: 4,981,874

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Claims for Patent: 4,981,874

Title: Medicaments
Abstract:A method and certain compositions for treating Pneumocystis carinii infections in a mammal by administering a certain naphthoquinone compound or physiologically acceptable salts thereof.
Inventor(s): Latter; Victoria S. (Beckenham, Kent, GB2), Gutteridge; Winston E. (Beckenham, Kent, GB2)
Assignee:
Application Number:07/394,378
Patent Claims: 1. A method of treating a Pneumocystis carinii infection in a mammal which comprises administering to said mammal having said infection an effective Pneumocystis carinii treatment amount of a naphthoquinone of the general formula (II): ##STR3## or a physiologically acceptable salt thereof.

2. A method according to claim 1 wherein in the compound 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone or a physiologically acceptable salt thereof is administered.

3. A method according to claim 1 or claim 2 wherein the compound or salt of formula (II) is administered in an amount of from 10 to 50 mg per kilogram of mammal body weight per day.

4. A method according to claim 1 wherein the mammal is a human.

5. A method according to claim 2 wherein the mammal is a human.

6. A method according to claim 3 in which the mammal is a human.

7. A method of claims 1, 2, 3, 4, 5 or 6 in which the mammal has an HIV infection.

8. A method of treating Pneumocystis carinii infection in a mammal, which comprises administering to a mammal having said infection an effective Pneumocystis carinii treatment amount of 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone.

9. A method according to claim 8, in which the mammal is a human.

10. A method according to claim 1, 2 or 8, wherein the compound of formula (II) or a physiologically acceptable salt thereof is administered nasally.

11. A method according to claim 1, 2 or 8, wherein the compound of formula (II) or a physiologically acceptable salt thereof is administered parenterally.

12. A method according to claim 1, 2 or 8, wherein the compound of formula (II) or a physiologically acceptable salt thereof is administered orally.

13. A method according to claim 1, 2 or 8, wherein the compound of formula (II) or a physiologically acceptable salt thereof is given by pulmonary administration.

14. A method according to claim 1, 2 or 8, wherein the infection is Pneumocystis carinii pneumonia.

15. A method of preventing Pneumocystis carinii infections in an immunocompromised mammal which comprises administering to said mammal an effective P.carinii prevention amount of a naphthoquinone of the general formula (II): ##STR4## or a physiologically acceptable salt thereof.

16. A method according to claim 15 wherein the compound of formula (II) is 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone or a physiologically acceptable salt thereof is administered.

17. A method according to claim 15 or claim 16 wherein the compound of formula (II) is administered in an amount of from 10 to 50 mg per kilogram of mammal body weight per day.

18. The method of claims 15, 16 or 17 in which the mammal has an HIV infection and is a human.

19. The method of claims 15, 16 or 17 in which the mammal is a human.

20. A method of preventing Pneumocystis carinii infections in an immunocompromised mammal, which comprises administering to said mammal an effective Pneumocystis carinii prevention amount of

2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone.
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