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Claims for Patent: 4,980,171

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Claims for Patent: 4,980,171

Title: Pharmaceutical composition for oral administration, based on a diphosphonic acid derivative
Abstract:The invention relates to oral pharmaceutical compositions comprising a diphosphonic acid derivative and sodium laurylsulfate in the amount of 1.5 to 6% by weight, relative to the diphosphonic compound.
Inventor(s): Fels; Jean-Pierre (Castelnau le lez, FR), Gromenil; Jean-Claude (Montbazin-Poussan, FR), Abramovici; Bernard (Juvignac, FR)
Assignee: Societe Anonyme dite : SANOFI (Paris, FR)
Application Number:07/333,966
Patent Claims: 1. A pharmaceutical composition for oral administration, based on a diphosphonic acid derivative of the formula ##STR2## in which R.sub.1 represents a hydrogen atom, a halogen atom, a hydroxyl, an amino or a dialkyl(C.sub.1 -C.sub.4)amino, and

R.sub.2 represents a halogen atom, a linear alkyl containing from 1 to 5 carbon atoms which is unsubstituted or substituted by a chlorine atom, a hydroxyl, an amino or a dialkyl(C.sub.1 -C.sub.4)amino, or R.sub.2 represents a phenoxy, a phenyl, a thiol, a phenylthio, a chlorophenylthio, a pyridyl or a thiomorpholin-4-yl,

or one of its pharmaceutically acceptable salts, which comprises from 1.5 to 6% by weight of sodium laurylsulfate relative to the diphosphonic acid derivative.

2. A pharmaceutical composition according to claim 1, wherein the diphosphonic acid derivative is selected from etidronic acid, piridronic acid, clodronic acid, pamidronic acid, 4-chlorophenylthiomethylenediphosphonic acid, 4-amino-1-hydroxybutylidenediphosphonic acid, 6-amino-1-hydroxyhexylidenediphosphonic acid, phenoxymethylenediphosphonic acid, thiomorpholinomethylenediphosphonic acid or one of their pharmaceutically acceptable salts.

3. A pharmaceutical composition according to claim 1, in which the diphosphonic acid derivative is 4-chlorophenylthiomethylenediphosphonic acid or its disodium salt.

4. A pharmaceutical composition according to claim 1, comprising from 100 to 500 mg of 4-chlorophenylthiomethylenediphosphonic acid or the equivalent amount of its disodium salt, and from 1.7 to 4% by weight of sodium laurylsulfate.
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