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Claims for Patent: 4,978,655

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Claims for Patent: 4,978,655

Title: Use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with retroviruses
Abstract:This invention relates to the use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with a retrovirus.
Inventor(s): Lin; Tai-Shun (North Haven, CT), Prusoff; William H. (North Branford, CT)
Assignee: Yale University (New Haven, CT)
Application Number:06/942,666
Patent Claims: 1. A method for treating warm blooded animals infected with a retrovirus, the method comprising administering to the warm blooded animal an anti-retroviral effective amount of 3'-deoxythymidin-2'-ene, either alone or in admixture with a diluent or in the form of a medicament.

2. A method according to claim 1, wherein the retrovirus is Moloney murine leukemia virus.

3. A method according to claim 1, wherein the retrovirus is HTLV III/LAV.

4. A method according to claim 1, wherein the 3'-deoxythymidine-2'-ene is administered intravenously in an amount of 0.01 to 10 mg per kg body weight per day.

5. A method according to claim 1 wherein the 3'-deoxythymidin-2'-ene is in admixture with a solid, liquid or liquified gaseous diluent to form a pharmaceutical composition.

6. A method according to claim 5, wherein the pharmaceutical composition contains 0.5 to 90% of said 3'-deoxythymidin-2'-ene.

7. A method according to claim 5, wherein the pharmaceutical composition is in the form of a sterile physiologically isotonic aqueous solution.

8. A method for treating human blood cells infected with HIV comprising administering to said cells an antiretroviral effective amount of 3'-deoxythymidin-2'-ene either alone or in admixture with a diluent or in the form of a medicament.
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