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Last Updated: March 26, 2026

Claims for Patent: 4,966,891

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Summary for Patent: 4,966,891

Title:	Fluorocytidine derivatives
Abstract:	The novel 5'-deoxy-5-fluorocytidine derivatives of formula (I) wherein R1, R2 and R3 are hydrogen or an easily hydrolyzable radical under physiological conditions, with the proviso that, at least one or R1, R2 and R3 is an easily hydrolyzable radical under physiological conditions, as well as hydrates of solvates of these compounds have antitumor properties. They can be prepared from compounds of formula I, wherein R1 is hydrogen or an amino-protecting radical and R2 and R3 are hydrogen or a hydroxy-protecting radical or taken together are a cyclic hydroxy-protecting radical.
Inventor(s):	Morio Fujiu, Hideo Ishitsuka, Masanori Miwa, Isao Umeda, Kazuteru Yokose
Assignee:	Hoffmann La Roche Inc
Application Number:	US07/268,437
Patent Claims:

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