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Claims for Patent: 4,963,555

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Claims for Patent: 4,963,555

Title: Formulations of heterocyclic compounds
Abstract:A topical pharmaceutical formulation for use in treating virus infections of the skin or mucosa and containing 9-(2-hydroxyethoxymethyl) guanine or a salt or ester thereof which comprises a dispersed oil phase and a continuous aqueous phase containing therein water, at least 30% of a polyhydric alcohol (by weight of the formulation) and solublized acyclovir.
Inventor(s): Jones; Trevor M. (Sanderstead, GB2), White; Alan R. (Meopham, GB2)
Assignee: Burroughs Wellcome Co. (Research Triangle Park, NC)
Application Number:07/317,129
Patent Claims: 1. An oil-in-water topical formulation of an effective antiviral non-toxic amount of 9-(2-hydroxyethoxymethyl)guanine or a pharmaceutically acceptable salt thereof, having a dispersed oil phase and a continuous aqueous phase, said aqueous phase containing therein water, 30% to 50% w/w of a water miscible polyhydvic alcohol, and an effective antiviral non-toxic amount solubillised 9-(2-hydroxyethoxymethyl)guanine or said salt thereof.

2. A formulation according to claim 1 comprising from 1% to 10% w/w 9-(2-hydroxyethoxymethyl)guanine or said salt thereof, from 30% to 50% w/w of said propylene glycol, from 20% to 40% w/w water together with said oil phase.

3. A formulation according to claim 1 wherein said polyhydric alcohol is a glycol or macrogol.

4. A formulation according to claim 3 wherein said glycol or macrogol is selected from a group consisting of propylene glycol, butane 1,3-diol, glycerol and polyethylene glycol.

5. A method of treating or preventing viral infections of the skin or mucosa of a mammal comprising applying the topical an effective amount of the formulation according to claim 1 to the selected area of skin or mucosa from 2 to 6 times daily.

6. A method of treating or preventing Herpes simplex infections of the skin or mucosa of a mammal comprising applying the topical an effective amount of the formulation according to claim 1 to the selected area of skin or mucosa from 2 to 6 times daily.

7. A method for treating or preventing Herpes zoster infections of the skin or mucosa of a mammal comprising applying the topical an effective amount of the formulation according to claim 1 to the selected area of skin or mucosa from 2 to 6 times daily.

8. A method for treating or preventing Herpes varicella infections of the skin or mucosa of a mammal comprising applying the topical an effective amount of the formulations according to claim 1 to the selected area of the skin or mucosa from 2 to 6 times daily.

9. A topical cream comprising about 2% to about 5% w/w of micronized acyclovir or a pharmaceutically acceptable salt thereof and greater than about 30% w/w of propylene glycol.

10. A topical cream comprising about 5% w/w micronized acyclovir or a pharmaceutically acceptable salt thereof and about 40% w/w of propylene glycol.

11. An oil in water emulsion topical formulation of an effective antiviral nontoxic amount of 9-(2-hydroxyethoxymethyl)guanine or a pharmaceutically acceptable salt thereof comprising about 5% w/w of 9-(2-hydroxyethoxymethyl)guanine or a pharmaceutically acceptable salt thereof and about 40% w/w of propylene glycol in an aqueous phase thereof.

12. A method of treating a herpes viral infection of the skin or mucosa of a mammal which comprises applying to the skin or mucosa an effective herpes antiviral treatment amount of an oil in water topical formulation comprising about 5% w/w of solubilized 9-(2-hydroxyethoxymethyl)guanine or a pharmaceutically acceptable salt thereof and about 40% w/w of propylene glycol in an aqueous phase thereof.

13. An oil in water emulsion topical formulation of an effective antiviral amount of 9-(2-hydroxyethoxymethyl)guanine or a pharmaceutically acceptable salt thereof comprising about 5% w/w of 9-(2-hydroxyethoxymethyl)guanine or a pharmaceutically acceptable salt thereof and about 30 to 50% w/w of propylene glycol in an aqueous phase thereof.

14. A method of treating a herpes viral infection of the skin or mucosa of a mammal which comprises applying to the skin an effective herpes antiviral treatment amount of an oil in water topical formulation comprising about 5% w/w of solubilized 9-(2-hydroxyethoxymethyl) or a pharmaceutically acceptable salt thereof and about 30 to 50% w/w of propylene glycol in an aqueous phase thereof.

15. An oil in water emulsion topical formulation comprising 5 to 10% of 9-(2-hydroxyethoxymethyl)guanine or a pharmaceutically acceptable salt thereof and about 30 to 50% w/w of propylene glycol.
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