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Claims for Patent: 4,957,730

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Claims for Patent: 4,957,730

Title: Antimycotic nail varnish
Abstract:A nail varnish comprising a water-insoluble film-forming substance and an antimycotic compound which is a 1-hydroxy-2-pyridone I of the general formula ##STR1## in which R.sup.1 is a hydrocarbon group which contains from 6 to 9 carbon atoms, but is free from olefinic and acetylenic bonds, one of the groups R.sup.2 and R.sup.4 is hydrogen and the other is hydrogen, methyl or ethyl and R.sup.3 is alkyl having up to two carbon atoms, said antimycotic ingredient being present in free form or in the form of a salt.
Inventor(s): Bohn; Manfred (Hofheim am Taunus, DE), Dittmar; Walter (Hofheim am Taunus, DE), Peil; Heinz G. (Bad Nauheim, DE), Futterer; Eberhard (Kelkheim, DE), Kraemer; Karl (Langen, DE)
Assignee: Hoechst Aktiengesellschaft (Frankfurt am Main, DE)
Application Number:06/942,699
Patent Claims: 1. A nail varnish comprising a water insoluble film-forming substance and an antimycotic compound which is a 1-hydroxy-2-pyridone of the formula (I) ##STR12## in which R.sup.1 is a hydrocarbon group which contains from 6 to 9 carbon atoms, but said hydrocarbon group being free from olefinic and acetylenic bonds, one of the groups R.sup.2 and R.sup.4 is hydrogen and the other is hydrogen, methyl or ethyl and R.sup.3 is alkyl having up to two carbon atoms, said antimycotic ingredient being present in free form or in the form of a salt, and in an amount effective against nail mycoses.

2. A nail varnish according to claim 1, wherein in compound I R.sup.2 and R.sup.4 are hydrogen.

3. A nail varnish according to claim 1, wherein the compound I R.sup.1 contains a cyclic group.

4. A nail varnish according to claim 3, wherein the group is a cyclohexyl group.

5. A nail varnish according to claim 1, wherein R.sup.1 is a cyclohexyl group.

6. A nail varnish according to claim 2, wherein in compound I R.sup.1 contains a cyclic group.

7. A nail varnish according to claim 6, wherein the cyclic group is a cyclohexyl group.

8. A nail varnish according to claim 1, wherein R.sup.1 is a cyclohexyl group and R.sup.2 and R.sup.3 are hydrogen.

9. A nail varnish according to claim 1, wherein in compound I R.sup.1 is an octyl group.

10. A nail varnish according to claim 2, wherein in compound I R.sup.1 is an octyl group.

11. A nail varnish according to claim 9, wherein the octyl group has the formula --CH.sub.2 --CH(CH.sub.3)--CH.sub.2 --C(CH.sub.3).sub.3.

12. A nail varnish according to claim 10, wherein the octyl group has the formula --CH.sub.2 --CH(CH.sub.3)--CH.sub.2 --C(CH.sub.3).sub.3.

13. A nail varnish according to claim 1, wherein compound I is contained in an amount of from 2 to 80% by weight, based on the amount of the non-volatile components.

14. A nail varnish according to claim 1, wherein compound I is contained in an amount of from 10 to 60% by weight, based of the amount of the non-volatile components.

15. A nail varnish according to claim 1, wherein compound I is contained in an amount of from 20 to 40% by weight, based on the amount of the non-volatile components.

16. A nail varnish according to claim 1, wherein compound I is contained in an amount of from 0.5 to 20% by weight.

17. A nail varnish according to claim 1, wherein compound I is contained in an amount of from 2 to 15% by weight.

18. A nail varnish according to claim 16, which is a medicated nail varnish and contains compound I in an amount of at least 4% by weight.

19. A nail varnish according to claim 16, wherein compound I is contained in an amount of less than 4% by weight.

20. A nail varnish according to claim 16, wherein compound I is contained in an amount of at least 1% by weight.

21. A method of treating onychromycosis which comprises applying to a nail infested by onchomycosis a nail varnish as defined in claim 1 and containing an effective amount of compound I.
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