|Title:||Non-ionic polyol contrast media from ionic contrast media|
|Abstract:||Novel non-ionic contrast media of a hitherto unknown combination of low osmolality and low viscosity are efficiently prepared from generally available ionic contrast media or non-iodinated precursors. Particularly, polyhydroxyhalo-hydrocarbons are employed with a triiodo-substituted acylamido benzoic acids in aqueous weakly basic media to selectively substitute the amido nitrogen, followed by activation of the carboxyl group for amide formation.|
|Inventor(s):||Sovak; Milos (Rancho Santa Fe, CA), Ranganathan; Ramachandran (Princeton, NJ)|
|Assignee:||Cook Imaging Corporation (Bloomington, IN)|
1. A contrast medium formulation comprising 5-(N-2,3-dihydroxypropylacetamido)-2,4,6-triiodo-N-(23-dihydroxypropyl)-N' -(2-hydroxyethyl)-isophthalamide in a physiologically
acceptable medium at a concentration in the range of about 50 to 400 mg I/ml.
2. 5-(N-b 2,3-dihydroxypropylacetamido)-2,4,6-triiodo-N-(2-3,-dihydroxypropyl)-N'-( 2-hydroxyethyl)-isophthalamide.