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|Title:||Method for treating nocturnal angina|
|Abstract:||A medical bandage is disclosed comprising a reservoir containing a gelled fluid, rheological agent and a drug. A method of using the bandage for producing a beneficial effect is disclosed also.|
|Inventor(s):||Gale; Robert M. (Mountain View, CA)|
|Assignee:||Alza Corporation (Palo Alto, CA)|
1. A method for diminishing the occurrence of nocturnal angina attacks in a patient, which method comprises:
(a) positioning on the skin at a location selected from the group consisting of arm, abdomen, chest, back, thigh, leg and buttocks of a patient prone to nocturnal anginal attacks, a medical bandage comprising:
(1) a backing member that is substantially impermeable to the passage of drug;
(2) a reservoir in contact with the backing member, the reservoir comprising an oil selected from the group consisting of natural and synthetic oils, rheological means for increasing the viscosity of the oil, and a drug useful for diminishing the occurrence of nocturnal anginal attacks;
(3) a rate controlling membrane in contact with the backing member and the reservoir comprising a polymeric composition that aids in controlling the release of the drug from the medical bandage; and,
(b) administering transdermally the drug to the patient in a therapeutically effective amount of producing the intended therapy.
2. The method for diminishing the occurrence of nocturnal anginal attacks according to claim 1, wherein an adhesive is in contact with the medical bandage, which adhesive holds the medical bandage on the skin.
3. The method for diminishing the occurrence of nocturnal anginal attacks according to claim 1, wherein an adhesive and a protective liner are in contact with the medical bandage, which liner is pulled from the medical bandage before it is positioned on the skin.
4. The method for diminishing the occurrence of nocturnal anginal attacks according to claim 1, wherein more than one of said medical bandages is positioned on the skin at the same time.
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