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Claims for Patent: 4,948,805

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Claims for Patent: 4,948,805

Title: Salt of diclofenac with a pyrrolidine compound and pharmaceutical compositions which contain it
Abstract:The salt of diclofenac with a cyclic organic base is prepared by dissolving diclofenac in a suitable organic solvent, adding said cyclic organic base, reacting the two components together, removing the solvent and crystallizing the product obtained. Said salt is water soluble to an extent from 20% w/v to an extent exceeding 50% w/v, and is used to prepared pharmaceutical compositions preferably in granular form for use by dissolving in water for oral administration.
Inventor(s): Ziggiotti; Antonio (Vezia, CH), Di Schiena; Michele (Cisliano, IT)
Assignee: Altergon S. A. & Ricerfarma Srl. (IT)
Application Number:07/117,823
Patent Claims: 1. A water soluble salt, comprising:

diclofenac (2-[(-2,6-dichlorophenyl)-amino-]benzeneacetic acid); and

a cyclic organic base having the formula ##STR2## wherein n is 2.

2. A pharmaceutical composition comprising a therapeutically active quantity of a water soluble salt of diclofenac and a cyclic organic base having the formula ##STR3## wherein n is 2, together with a pharmaceutically acceptable excipient.

3. The composition of claim 2, wherein a quantity of the salt of diclofenac and said cyclic organic base corresponding to 10-200 mg of diclofenac per unit dosage is present.

4. The composition of claim 2, wherein said composition is in granular form and is packaged in a water-impermeable sachet.
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