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Claims for Patent: 4,929,629

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Claims for Patent: 4,929,629

Title: Therapeutic compound
Abstract:N,N-Dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate is a non-hygroscopic material which can be used as a pharmaceutical in the treatment of depression.
Inventor(s): Jeffery; James E. (Nottingham, GB2)
Assignee: Boots Company, PLC (Nottingham, GB2)
Application Number:07/342,638
Patent Claims: 1. An N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate product in crystalline solid form essentially comprising equimolar amounts of N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride and molecularly combined water of hydration, said product exhibiting substantially non-hydroscopic properties when exposed to atmospheric moisture environmental conditions.

2. A pharmaceutical composition comprising an antidepressantly effective amount of the N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate product of claim 1 in combination with a pharmaceutically acceptable diluent or carrier.

3. A method of treating depression in humans which comprises administering to a human in need thereof an antidepressantly effective amount of the composition of claim 2.
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