Claims for Patent: 4,920,143

Summary for Patent: 4,920,143

Title:	Hydro-monobenzoporphyrin wavelength-specific cytotoxic agents
Abstract:	A group of hydro-monobenzoporphyrins "green porphyrins" (Gp) having absorption maxima in the range of 670-780 nanometers is useful in treating disorders or conditions which are subject to hematoporphyrin derivative (HPD) treatment in the presence of light, or in treating virus, cells and tissues generally to destroy unwanted targets. The use of the Gp of the invention permits the irradiation to use wavelengths other than those absorbed by blood. The Gp of the invention may also be conjugated to ligands specific for receptor or to specific immunoglobulins or fragments thereof to target specific tissues or cells for the radiation treatment. Use of these materials permits lower levels of drug to be used, thus preventing side reactions which might destroy normal tissues.
Inventor(s):	Julia G. Levy, David Dolphin, Jack K. Chow, Ethan Sternberg
Assignee:	BRITISH COLUMBIA A CORP OF VANCOUVER BC CANADA, University of , University of British Columbia
Application Number:	US07/221,161
Patent Claims:	1. A compound of the formula ##STR7## wherein each R1 and R2 is independently selected from the group consisting of carbalkoxy (1-6C), alkyl (1-6C) sulfonyl, aryl sulfonyl, and aryl, andeach R3 is independently CH2 CH2 COOR3' where R3' is H or alkyl (1-6C); and R4 is CHCH2, CH2 OR4', CH(OR4')CH3, CH(OR4')CH2 OR4', --CH(SR4')CH3, --CH(NR4' 2)CH3, --CH(CN)CH3, --CH(COOR4')CH3, --CH(OOCR4', )CH3, --CH(halo)CH3, and --CH(halo)CH2 (halo), wherein R4' is H, alkyl (1-6C), with the proviso that if R4 is CHCH2, both R3', cannot be alkyl. 2. The compound of claim 1 wherein R1 and R2 are carbalkoxy. 3. The compound of claim 2 wherein R1 and R2 are carbomethoxy or carboethoxy. 4. The compound of claim 2 which is of formulae mulae 3 or 4 of FIG. 1. 5. The compound of claim 2 wherein R4 is selected from --CHCH2, --CH(OH)CH3 and --CH(halo)CH3. 6. The compound of claim 2 which is selected from compounds of the formula ##STR8## wherein R is alkyl (1-6C). 7. The compound of claim 5 which is of the formula 8. A pharmaceutical composition which is useful in targeting specific biological material which composition comprises an effective amount of the compound of claim 1 in admixture with at least one pharmaceutically acceptable excipient. 9. A pharmaceutical composition which is useful in targeting specific biological material which composition comprises an effective amount of the compound of claim 5 in admixture with at least one pharmaceutically acceptable excipient. 10. A pharmaceutical composition which is useful in targeting specific biological material which composition comprises an effective amount of the compound of claim 6 in admixture with at least one pharmaceutically acceptable excipient. 11. A pharmaceutical composition which is useful in targeting specific biological material which composition comprises an effective amount of the compound of claim 7 in admixture with at least one pharmaceutically acceptable excipient.