.

Deeper Knowledge, Faster

  • Analyze global market entry opportunities
  • Identify first generic entrants
  • Uncover prior art in expired and abandoned patents

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving leading biopharmaceutical companies globally:

Novartis
AstraZeneca
Dow
Argus Health
Daiichi Sankyo
Covington
Accenture
Deloitte
McKinsey
Teva

Generated: December 14, 2017

DrugPatentWatch Database Preview

Claims for Patent: 4,918,068

« Back to Dashboard

Claims for Patent: 4,918,068

Title: Cephem compounds
Abstract:There are provided new cephem compounds (synisomers) represented by the following general formula (I): ##STR1## wherein R.sup.1 means a lower group, R.sup.2 denotes an ester-forming group of the carboxyl group, and the 4-methylthiazolyl group and the cephem moiety are cis to each other relative to the carbon-carbon double bond of the substituted vinyl group in the side chain at the 3-position of the cephem nucleus. The cephem compounds exhibit strong antibacterial activities not only against resistant strains of bacteria and gram-negative bacteria but also against gram-positive bacteria and moreover have very low toxicity.
Inventor(s): Yamamoto; Yuichi (Yokohama, JP), Atsumi; Kunio (Kawasaki, JP), Sakagami; Kenji (Kawasaki, JP), Yoshida; Takashi (Tokyo, JP), Nishihata; Ken (Yokohama, JP), Kondo; Sinichi (Yokohama, JP)
Assignee: Meiji Seika Kaisha, Ltd. (Tokyo, JP)
Application Number:07/019,172
Patent Claims: 1. The syn-isomer of a cephem compound represented by the following formula (I) ##STR7## wherein R.sup.1 means a lower alkyl group, R.sup.2 denotes a lower alkanoyloxyalkyl group, a lower alkoxycarbonyloxyalkyl group, phthalidyl group or (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl group of the carboxyl group, and the 4-methylthiazolyl group and the cephem moiety are cis to each other relative to the carbon-carbon double bond of the substituted vinyl group in the side chain at the 3-position of the cephem nucleus.

2. The compound as claimed in claim 1, wherein R.sup.1 is a methyl or ethyl group, and R.sup.2 is a pivaloyloxymethyl, acetoxymethyl, 1-acetoxyethyl, 1-ethoxycarbonyloxyethyl, phthalidyl or (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl group.

3. The compound as claimed in claim 2, which is pivaloyloxymethyl 7-[2-ethoxyimino-2-(2-aminothiazol-4yl)acetamido-]-3-[2-(4-methylthiazol-5 -yl)vinyl]-3-cephem-4-carboxylate.

4. The compound as claimed in claim 2, which is acetoxymethyl 7-[2-methoxyimino-2-(2-aminothiazol-4-yl)acetamido]-3-[2-(4-methylthiazol- 5-yl)vinyl]-3-cephem-4-carboxylate.

5. The compound as claimed in claim 2, which is 1-acetoxyethyl 7-[2-methoxyimino-2-(2-aminothiazol-4-yl)acetamido-]-3-[2-(4-methylthiazol -5-yl)vinyl]-3-cephem-4-carboxylate.

6. The compound as claimed in claim 2, which is 1-ethoxycarbonyloxyethyl 7-[2-methoxyimino-2-(2-aminothiazol-4-yl)acetamido]-3-[2-(4-methylthiazol- 5-yl)vinyl]-3-cephem-4-carboxylate.

7. The compound as claimed in claim 2, which is phthalidyl 7-[2-methoxyimino-2-(2-aminothiazol-4-yl)-acetamido]-3-[2-(4-methylthiazol -5-yl)vinyl]-3-cephem-4-carboxylate.

8. The compound as claimed in claim 2, which is (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl 7-[2-methoxyimino-2-(2-aminothiazol-4-yl)acetamido]-3-[2-(4-methylthiazol- 5-yl)vinyl]-3-cephem-4-carboxylate.

9. A pharmaceutical, antibacterial composition which comprises an antibacterially effective amount compound of the formula (I) as defined in claim 1 as the active ingredient, in combination with a pharmaceutically acceptable carrier for the active ingredient.
« Back to Dashboard

For more information try a trial or see the plans and pricing

Serving leading biopharmaceutical companies globally:

Cantor Fitzgerald
Teva
Covington
Citi
Boehringer Ingelheim
Daiichi Sankyo
US Army
Express Scripts
Medtronic
Queensland Health

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

Copyright 2002-2017 thinkBiotech LLC
ISSN: 2162-2639

Secure SSL Encrypted
Privacy and Cookies
Terms & Conditions

Follow DrugPatentWatch:

botpot