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Claims for Patent: 4,916,163

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Claims for Patent: 4,916,163

Title: Spray-dried lactose formulation of micronized glyburide
Abstract:An improved, more bioavailable formulation of glyburide is provided which consists preponderantly by weight of spray-dried lactose is described. This formulation utililzes micronized glyburide, but is more economically manufacatured than heretofore known micronized glyburide formulations.
Inventor(s): Ni; Philip F. (Texas Township, MI)
Assignee: The Upjohn Company (Kalamazoo, MI)
Application Number:06/741,241
Patent Claims: 1. In an micronized glyburide anti-diabetic pharmaceutical composition as a unit dose, containing one or more pharmaceutically acceptable excipients, the improvement which comprises:

spray-dried lactose as the preponderant excipient in said composition, being present therein at about not less that seventy percent (70%) by weight of the final composition.

2. The improvement according to claim 1 wherein the micronized glyburide has a surface area of about 5 m.sup.2 /g.

3. The improvement according to claim 1 wherein the excipients comprise a glidant, lubricant and disintegrant.

4. The improvement according to claim 1 wherein the excipients comprise corn starch, silicon dioxide, and magnesium stearate.
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