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|Title:||Spray-dried lactose formulation of micronized glyburide|
|Abstract:||An improved, more bioavailable formulation of glyburide is provided which consists preponderantly by weight of spray-dried lactose is described. This formulation utililzes micronized glyburide, but is more economically manufacatured than heretofore known micronized glyburide formulations.|
|Inventor(s):||Ni; Philip F. (Texas Township, MI)|
|Assignee:||The Upjohn Company (Kalamazoo, MI)|
1. In an micronized glyburide anti-diabetic pharmaceutical composition as a unit dose, containing one or more pharmaceutically acceptable excipients, the improvement which comprises:
spray-dried lactose as the preponderant excipient in said composition, being present therein at about not less that seventy percent (70%) by weight of the final composition.
2. The improvement according to claim 1 wherein the micronized glyburide has a surface area of about 5 m.sup.2 /g.
3. The improvement according to claim 1 wherein the excipients comprise a glidant, lubricant and disintegrant.
4. The improvement according to claim 1 wherein the excipients comprise corn starch, silicon dioxide, and magnesium stearate.
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