.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Claims for Patent: 4,911,920

« Back to Dashboard

Claims for Patent: 4,911,920

Title: Sustained release, comfort formulation for glaucoma therapy
Abstract:Disclosed are nonstinging, sustained release ophthalmic formulations to control intraocular pressure in antiglaucoma therapy comprising a basic active, a cation exchange resin, and, inter alia, an acidic, mucomimetic polymer. Also disclosed are methods of treatment comprising administering such formulations topically to the eye when indicated for control and lowering of intraocular pressure.
Inventor(s): Jani; Rajni (Fort Worth, TX), Harris; Robert G. (Fort Worth, TX)
Assignee: Alcon Laboratories, Inc. (Fort Worth, TX)
Application Number:07/154,514
Patent Claims: 1. A sustained release ophthalmic pharmaceutical composition in the form of an aqueous gel, a pourable aqueous dispersion, or anhydrous salt, for controlling and lowering intraocular pressure comprising:

a therapeutically effective amount of betaxolol;

an amount of an anionic mucomimetic polymer having carboxylic acid functional groups which comprise from 2 to 7 carbon atoms per functional group and a molecular weight of from 50,000 to 6 million such that the composition in the form of an aqueous gel or pourable aqueous dispersion has a viscosity of about 1 to about 20,000 cps.; and sodium poly(styrenedivinylbenzene) sulfonic acid at a concentration of from about 0.05% to 10.0% by weight, the composition having a pH of from about 3.0 to 8.5.

2. The composition according to claim 1 wherein the composition is an aqueous dispersion.

3. A composition according to claim 1 wherein the betaxolol is present at a concentration of from about 0.01 to 4.0 wt.%.

4. A composition according to claim 1 wherein the anionic mucomimetic polymer comprises carbomer.

5. A composition according to claim 1 wherein the betaxolol is present at a concentration of about 0.25 wt.%, the anionic mucomimetic polymer is carbomer present at a concentration of about 0.20 wt.%, and the sulfonic acid is present at a concentration of about 0.25 wt.%.

6. The composition of claim 1 wherein the particulate cation exchange resin is in the form of a finely divided powder, said powder consisting of spheroidal particles.

7. A method of treatment for controlling and lowering intraocular pressure which comprises administering topically to the affected eye a pharmaceutical composition which includes:

a therapeutically effective amount of betaxolol;

an amount of an anionic mucomimetic polymer having carboxylic acid functional groups which comprise from 2 to 7 carbon atoms per functional group and a molecular weight of from 50,000 to 6 million such that the composition in the form of an aqueous gel or pourable aqueous dispersion has a viscosity of about 1 to about 20,000 cps.; and sodium poly(styrene-divinylbenzene) sulfonic acid at a concentration of from about 0.05% to 10.0% by weight, the composition having a pH of from about 3.0 to 8.5.

8. The method according to claim 7 wherein the composition is an aqueous dispersion.

9. A method according to claim 7 wherein the betaxolol is present at a concentration of from about 0.01 to 4.0 wt.%.

10. A method according to claim 7 wherein the anionic mucomimetic polymer comprises carbomer.

11. A method according to claim 7 wherein the betaxolol is present at a concentration of about 0.25 wt.%, the anionic mucomimetic polymer is carbomer present at a concentration of about 0.20 wt.%, and the sodium poly(styrene-divinylbenzene) sulfonic acid is present at a concentration of about 0.25 wt.%.

12. The method of claim 7 wherein the particulate cation exchange resin is in the form of a finely divided powder, said powder consisting of spheroidal particles.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

How are People Using DrugPatentWatch?

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc