.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Claims for Patent: 4,910,225

« Back to Dashboard

Claims for Patent: 4,910,225

Title: Locally administrable therapeutic composition for inflammatory disease
Abstract:This invention relates to a locally administrable therapeutic composition for inflammatory disease which is characterized by comprising benzoylphenylacetic acid of the formula ##STR1## (wherein R is a hydrogen or halogen atom), or a salt thereof, or the hydrate of said acid or salt, as active ingredient. An ophthalmic composition according to the invention can treat effectively inflammatory eye disease by topical application, is not an irritant to the eye, and has a superior effect to conventional drugs of the same or similar type. The aqueous composition prepared in accordance with this invention has excellent stability and can be used advantageously as a nasal or otic composition as well as an ophthalmic one in the treatment of inflammatory otic or nasal disease.
Inventor(s): Ogawa; Takahiro (Nishinomiya, JP), Kuribayashi; Yoshikazu (Kobe, JP), Ushio; Kazumichi (Nishinomiya, JP), Ohtori; Akira (Nara, JP)
Assignee: Senju Pharmaceutical Co., Ltd. (Osaka, JP) A. H. Robins Company, Incorporated (Richmond, VA)
Application Number:07/301,033
Patent Claims: 1. A locally administrable opthalmic, otic or nasal therapeutic composition for the treatment of inflammatory disease of the eye, ear or nasal passage which comprises an anti-inflammatory effective amount of a benzoylphenylacetic acid of the formula ##STR3## wherein R is hydrogen or a halogen atom or a pharmaceutically acceptable salt thereof or a hydrate of said acid or salt in admixture with

(a) an isotonizing agent, and

(b) at least one member of the group consisting of a microbial agent and a preservative.

2. The locally administrable therapeutic composition for inflammatory disease according to claim 1, wherein the water-soluble polymer is polyvinyl pyrrolidone, polyvinyl alcohol, carboxypropylcellulose, hydroxyethylcellulose, hydroxypropylcellulose or sodium salt of polyacrylic acid.

3. The locally administrable therapeutic composition for inflammatory disease according to claim 1, wherein the concentration of the water-soluble polymer is in the range of about 0.1-10 W/W %.

4. The locally administrable therapeutic composition for inflammatory disease according to claim 1, wherein the sulfite is in the form of sodium, potassium, calcium or magnesium salt.

5. The locally administrable therapeutic composition for inflammatory disease according to claim 1, wherein the concentration of the sulfite is in the range of about 0.1-1 W/W %.

6. A composition according to claim 1 in the form of an aqueous solution.

7. A method of treating animals or humans to alleviate inflammation of the eye, nasal passage or ear canal which comprises applying to the eye, nasal passage or ear canal an anti-inflammatory effective amount of a compound of the formula: ##STR4## wherein R is hydrogen or a halogen atom or a pharmaceutically acceptable salt thereof, or a hydrate of said acid or salt, as active ingredient.

8. In a locally administrable stable aqueous therapeutic composition for use in the treatment of inflammatory disease comprising an anti-inflammatory effective amount of a benzoylphenylacetic acid of the formula ##STR5## wherein R is hydrogen or a halogen atom, or a pharmaceutically acceptable salt thereof, or a hydrate of said acid or salt, the improvement wherein said composition contains a stabilizing amount of a water-soluble polymer and a sulfite, the pH of said composition being in the range of about 6-9.

9. A locally administrable opthalmic ointment for the treatment of inflammatory disease of the eye which comprises an anti-inflammatory effective amount of a benzoylphenylacetic acid of the formula ##STR6## wherein R is hydrogen or a halogen atom or a pharmaceutically acceptable salt thereof or a hydrate of said acid or salt in admixture with an eye ointment base.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

How are People Using DrugPatentWatch?

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc