.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Claims for Patent: 4,904,769

« Back to Dashboard

Claims for Patent: 4,904,769

Title: Highly pure acarbose
Abstract:A purified acarbose which contains less than 10% by weight of sugar-like secondary components is obtained by column chromatograph of a solution of prepurified acarbose with a pH 4 to 7. The column contains as a packing material a weakly acid cation exchanger which has carboxyl groups and is based on dextran, agarose and cellulose or exchangers which are derived from the latter with the addition of polyamide.
Inventor(s): Rauenbusch; Erich (Wuppertal, DE)
Assignee: Bayer Aktiengesellschaft (Leverkusen, DE)
Application Number:06/940,713
Patent Claims: 1. A purified acarbose composition which, apart from water, has an acarbose content of about 93-98% by weight.

2. An acarbose composition according to claim 1, which, apart from water, contains 2 to 5% by weight of sugar-like secondary components.

3. An acarbose composition according to claim 1, which, apart from water, contains less than 2% by weight of sugar-like secondary components.

4. A process for the preparation of a purified acarbose composition according to claim 1, comprising applying a prepurified acarbose in a 1 to 20% by weight aqueous solution with a pH of 3.5 to 7 to a column which contains as packing material a weekly acid cation exchanger which has carboxyl groups and is based on dextran, agarose and cellulose or exchangers which are derived from the latter with the addition of polyamide, eluting the column exclusively with degassed, distilled water and isolating the purified acarbose composition from the eluate.

5. A process according to claim 4, wherein the volume of prepurified acarbose solution which is applied corresponds to the filling volume of the column.

6. A process according to claim 4, wherein the volume of prepurified acarbose solution is less than 60% of the column volume.

7. A process according to claim 4, wherein the pH of the prepurified acarbose solution is 3.5 to 6.0.

8. A process according to claim 4, wherein the pH of the prepurified acarbose solution is 4.0 to 5.5.

9. A process according to claim 4, wherein the prepurified acarbose solution is applied at temperatures up to room temperature, and, the column is heated to 25.degree. to 95.degree. C. after the salts and coloring constituents have been eluted therefrom.

10. A process according to claim 9, wherein the prepurified acarbose solution is applied at temperatures in the range from 4.degree. to 25.degree. C., and, after the salts and coloring constituents have been eluted, the column is heated to 40.degree. to 70.degree. C.

11. A pharmaceutical composition comprising an effective amount of an acarbose composition according to claim 1, said acarbose, apart from water, contains less than 10% by weight of sugar-like secondary components and a pharmaceutically acceptable excipient therefor.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

How are People Using DrugPatentWatch?

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc