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Claims for Patent: 4,904,650

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Claims for Patent: 4,904,650

Title: Substituted androsta-1,4-diene-3,17-diones
Abstract:The invention relates to 6-alkylidenadrosta-1,4-diene-3,17-dione derivatives, having the following general formula ##STR1## wherein each of R and R.sub.2, independently, is hydrogen or C.sub.1 -C.sub.6 alkyl and R.sub.1 is hydrogen, halogen or C.sub.1 -C.sub.6 alkyl, which are useful in therapy, in particular in the treatment of hormone-dependent cancers.
Inventor(s): Buzzetti; Franco (Monza, IT), Barbugian; Natale (Milan, IT), Lombardi; Paolo (Milan, IT), di Salle; Enrico (Milan, IT)
Assignee: Farmitalia Carlo Erba S.p.A. (Milan, IT)
Application Number:07/225,674
Patent Claims: 1. A compound of general formula (I) ##STR10## wherein each of R and R.sub.2, independently, is hydrogen or C.sub.1 -C.sub.6 alkyl and R.sub.1 is hydrogen, halogen or C.sub.1 -C.sub.6 alkyl.

2. A compound of formula (I), according to claim 1, wherein

R is hydrogen or C.sub.1 -C.sub.4 alkyl;

R.sub.1 is hydrogen, fluorine, chlorine or C.sub.1 -C.sub.4 alkyl; and

R.sub.2 is hydrogen or C.sub.1 -C.sub.4 alkyl.

3. A compound of formula (I), according to claim 1, wherein

R is hydrogen, methyl or ethyl;

R.sub.1 is hydrogen, fluorine or chlorine and

R.sub.2 is hydrogen.

4. A pharmaceutical composition containing a suitable carrier and/or diluent and, as an active principle, a therapeutically effective amount of a compound of claim 1, or a pharmaceutically acceptable salt thereof.

5. A pharmaceutical composition, suitable for the treatment of advanced hormone-dependent breast, pancreatic, endometrial or ovarian cancers, comprising, as an active principle, a therapeutically effective amount of a compound of claim 1, in association with a suitable carrier and/or diluent.

6. A pharmaceutical composition, suitable for the treatment of prostatic hypertrophy or prostatic hyperplasia, comprising, as an active principle, a therapeutically effective amount of a compound of claim 1, in association with a suitable carrier and/or diluent.

7. A method for the treatment of advanced hormone-dependent breast, pancreatic, endometrial or ovarian cancer comprising administering patients in need of such treatment an effective amount of a compound of claim 1.

8. A method for the treatment of prostatic hypertrophy or prostatic hyperplasia comprising administering to patients in need of such treatment an effective amount of a compound of claim 1.
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