Last Updated: May 11, 2026

Claims for Patent: 4,904,650

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Summary for Patent: 4,904,650

Title:	Substituted androsta-1,4-diene-3,17-diones
Abstract:	The invention relates to 6-alkylidenadrosta-1,4-diene-3,17-dione derivatives, having the following general formula ##STR1## wherein each of R and R2, independently, is hydrogen or C1 -C6 alkyl and R1 is hydrogen, halogen or C1 -C6 alkyl, which are useful in therapy, in particular in the treatment of hormone-dependent cancers.
Inventor(s):	Franco Buzzetti, Natale Barbugian, Paolo Lombardi, Enrico DI Salle
Assignee:	Pfizer Italia SRL
Application Number:	US07/225,674
Patent Claims:	1. A compound of general formula (I) ##STR10## wherein each of R and R2, independently, is hydrogen or C1 -C6 alkyl and R1 is hydrogen, halogen or C1 -C6 alkyl. 2. A compound of formula (I), according to claim 1, whereinR is hydrogen or C1 -C4 alkyl; R1 is hydrogen, fluorine, chlorine or C1 -C4 alkyl; and R2 is hydrogen or C1 -C4 alkyl. 3. A compound of formula (I), according to claim 1, whereinR is hydrogen, methyl or ethyl; R1 is hydrogen, fluorine or chlorine and R2 is hydrogen. 4. A pharmaceutical composition containing a suitable carrier and/or diluent and, as an active principle, a therapeutically effective amount of a compound of claim 1, or a pharmaceutically acceptable salt thereof. 5. A pharmaceutical composition, suitable for the treatment of advanced hormone-dependent breast, pancreatic, endometrial or ovarian cancers, comprising, as an active principle, a therapeutically effective amount of a compound of claim 1, in association with a suitable carrier and/or diluent. 6. A pharmaceutical composition, suitable for the treatment of prostatic hypertrophy or prostatic hyperplasia, comprising, as an active principle, a therapeutically effective amount of a compound of claim 1, in association with a suitable carrier and/or diluent. 7. A method for the treatment of advanced hormone-dependent breast, pancreatic, endometrial or ovarian cancer comprising administering patients in need of such treatment an effective amount of a compound of claim 1. 8. A method for the treatment of prostatic hypertrophy or prostatic hyperplasia comprising administering to patients in need of such treatment an effective amount of a compound of claim 1.

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