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Summary for Patent: 4,894,369
|Title:||Novel 2.beta.-morpholino-androstane derivatives|
|Abstract:||Compounds having the formula: ##STR1## wherein R.sub.1 is H or an optionally substituted acyl group having 1-12 carbon atoms, R.sub.2 is H or an acyl group having 1-12 carbon atoms and R.sub.3 is C, N--CH.sub.3 or a direct bond; and mono- or bisquaternary ammonium compounds thereof and acid addition salts of the non- or mono-quaternary ammonium compounds. Process for the preparation of these compounds. Compositions comprising at least one of the above compounds as the active ingredient. The compounds are favorable neuromuscular blocking agents.|
|Inventor(s):||Sleigh; Thomas (Wishaw, GB6), Savage; David S. (New Mearns, GB6), Carlyle; Ian C. (Hamilton, GB6)|
|Assignee:||Akzo N.V. (Arnhem, NL)|
1. Compounds having the formula: ##STR4## wherein R.sub.1 is H or an optionally substituted acyl group having 1-12 carbon atoms,
R.sub.2 is H or an acyl group having 1-12 carbon atoms and
R.sub.3 is C, N--CH.sub.3 or a direct bond, and mono- or bisquaternary ammonium compounds thereof and acid addition salts of the non- or mono-quaternary ammonium compounds.
2. Compounds according to claim 1, wherein R.sub.1 is H.
3. Compounds according to claim 1, wherein the compounds are 16.beta.-monoquaternary ammonium compounds.
4. Compounds according to claim 1, wherein R.sub.2 is a saturated acyl group having 1-6 carbon atoms.
5. Compounds according to claim 1, wherein R.sub.3 is C or a direct bond.
6. Compositions having neuromuscular blocking activity comprising an aqueous solution of at least one of the compounds claimed in claim 1 in a pharmaceutically effective amount.
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