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Last Updated: December 15, 2025

Claims for Patent: 4,894,240

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Summary for Patent: 4,894,240

Title:	Controlled absorption diltiazem formulation for once-daily administration
Abstract:	A diltiazem pellet formulation for oral administration comprises a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid, and a multi-layer membrane surrounding the core and containing a major proportion of a pharmaceutically acceptable film-forming, water insoluble synthetic polymer and a minor proportion of a pharmaceutically acceptable film-forming, water soluble synthetic polymer. The number of layers in the membrane and the ratio of the water soluble to water insoluble polymer being effective to permit release of the diltiazem from the pellet at a rate allowing controlled absorption thereof over a twenty four hour period following oral administration.
Inventor(s):	Edward J. Geoghegan, Seamus Mulligan, Donald E. Panoz
Assignee:	Elan Pharma International Ltd
Application Number:	US07/121,225
Patent Claims:

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