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Claims for Patent: 4,894,220

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Claims for Patent: 4,894,220

Title: Antibacterial antiplaque oral composition
Abstract:An oral composition such as a dentifrice or mouthwash, containing an aqueous phase of water and as solubilizing agent propylene glycol, dipropylene glycol, methyl cellosolve, ethyl cellosolve, olive oil, castor oil, amyl acetate, ethyl acetate, glyceryl tristearate or benzyl benzoate mixed with at least one of glycerine and sorbitol, a substantially water-insoluble noncationic antibacterial antiplaque agent, such as 2,4,4'-trichloro-2.sup.1 -hydroxydiphenyl ether (triclosan), and a synthetic anionic linear polymeric polycarboxylate having a molecular weight of about 1,000 to about 1,000,000.
Inventor(s): Nabi; Nuran (North Brunswick, NJ), Gaffar; Abdul (Princeton, NJ)
Assignee: Colgate-Palmolive Company (New York, NY)
Application Number:07/291,712
Patent Claims: 1. An oral composition comprising in an orally acceptable vehicle, a water-humectant phase, said water and humectant comprising at least about 10% by weight of said oral composition, an efective antiplaque amount of a substantially water insoluble noncationic antibacterial agent selected from the group consisting of halogenated diphenyl ethers and about 0.0005-4% by weight of a systematic anionic linear polymeric polycarboxylate having a molecular weight of about 1,000 to about 1,000,000, wherein said humectant includes a solubilizing agent selected from the group consisting of propylene glycol, dipropylene glycol, methyl cellosolve, ethyl cellosolve, olive oil, castor oil, amyl acetate, ethyl acetate, glyceryl tristearate and benzyl benzoate mixed with at least one of glycerine and sorbitol, the amount of said solubilizing humectant being sufficient to dissolve said antibacterial agent.

2. The oral composition claimed in claim 1 containing about 0.5-50% by weight of propylene glycol.

3. The oral composition claimed in claim 2 containing about 0.01-5% by weight of said antibacterial agent, wherein said antibacterial agent is a halogenated diphenyl ether.

4. The oral composition claimed in claim 3 wherein said antibacterial agent is present in amount of about 0.1-0.5%.

5. The oral composition claimed in claim 3 wherein said halogenated diphenyl ether is 2,4,4'-trichloro-2-hydroxy-diphenyl ether.

6. The oral composition claimed in claim 1 wherein said polymeric polycarboxylate is present in amount of about 0.1 to 2% of a water soluble alkali metal or ammonium salt of a copolymer of vinyl methyl ether and maleic acid or anhydride having a molecular weight of about 30,000 to about 500,000.

7. The oral composition claimed in claim 1 containing an effective anticalculus amount of material comprising at least one linear molecularly dehydrated polyphosphate salt as essential anticalculus agent.

8. The oral composition claimed in claim 7 wherein said polyphosphate salt is present in amount of about 0.1-7% by weight and is tetrasodium pyrophosphate.

9. The oral composition in claim 7 wherein said composition contains an amount of fluoride ion source sufficient to supply 25 ppm. to 2,000 ppm. of fluoride ions.

10. The oral composition claimed in claim 7 wherein said fluoride source is sodium fluoride.

11. The oral composition claimed in claim 1 wherein said composition contains an amount of fluoride ion source sufficient to supply 25 ppm to 2000 ppm of fluoride ions.

12. The oral composition claimed in claim 1 wherein said oral composition contains a dentally acceptable water-insoluble polishing agent and said oral compositions is a toothpaste or dentifrice.

13. The oral composition claimed in claim 12 wherein said oral composition contains about 0.5-50% by weight of propylene glycol about 0.1-10% by weight a gelling agent and about 10-75% by weight of said polishing agent and said oral composition is a toothpaste or gel dentifrice.

14. The oral composition claimed in claim 13 wherein about 0.3% by weight of said antibacterial agent is present, about 0.1.5-2% by weight of said polycarboxylate is present and about 0.5-1% by weight of propylene glycol is present.

15. The oral composition claimed in claim 13 wherein said polishing material is a silica polishing material.

16. The oral composition claimed in claim 1 wherein said oral composition contains about 70-99.9% by weight of a mixture of water and alcohol in a weight ratio of from about 1:1 to about 20:1 and said oral composition is a mouthrinse.

17. The oral composition claimed in claim 16 wherein said alcohol is ethanol.

18. The oral composition claimed in claim 16 wherein about 5-20% by weight of propylene glycol is present.
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