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Claims for Patent: 4,886,789

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Claims for Patent: 4,886,789

Title: Peritoneal dialysis and compositions for use therein
Abstract:A peritoneal dialysis composition containing an osmotic agent comprising a glucose polymer mixture, said mixture including at least 15% by weight of glucose polymers having a D.P. (degree of polymerization) greater than 12. A method is provided for preparing the glucose polymers and a defined sterile aqueous solution of the same for use in peritoneal dialysis by introduction into the abdominal cavity. Also disclosed are methods of treating toxaemia caused by toxins arising from internal disorders of the body, such as hepatic encephalopathy, or which arise from external sources such as poisoning by overdoses of drugs or industrial and agricultural chemicals, e.g., paraquat.
Inventor(s): Milner; Jeremiah (Roscrea, IE)
Assignee: M. L. Laboratories PLC (London, GB2)
Application Number:07/335,778
Patent Claims: 1. A method of effecting peritoneal dialysis which comprises introducing into the abdominal cavity of a patient an aqueous peritoneal dialysis composition comprising a water soluble glucose polymer mixture derived from the hydrolysis of starch containing at least 36.7% by weight of glucose polymers having a degree of polymerization (D.P.) of more than 12 glucose units.

2. The method of claim 1 wherein the average molecular weight of the glucose polymer mixture is from 15,000 to 25,000.

3. The method of claim 1 wherein the average molecular weight of the glucose polymer mixture is from 18,000 to 22,000.

4. The method of claim 1, 2 or 3 wherein the glucose polymer mixture contains more than 50% by weight of glucose polymers having a degree of polymerization (D.P.) of more than 12 glucose units.

5. The method of claim 1, 2 or 3 wherein the glucose polymer mixture contains from 50 to 90% by weight of glucose polymers having a degree of polymerization (D.P.) of more than 12 glucose units.

6. The method of claim 1, 2 or 3 wherein the glucose polymer mixture contains from 75 to 100% by weight of glucose polymers having a degree of polymerization (D.P.) of more than 12 glucose units.

7. The method of claim 1, 2 or 3 wherein the glucose polymer mixture contains from 90 to 100% by weight of glucose polymers having a degree of polymerization (D.P.) of more than 12 glucose units.

8. The method of claim 1, 2 or 3 wherein the aqueous peritoneal dialysis composition contains from 2 to 10% w/v of said glucose polymer mixture.

9. The method of claim 1, 2 or 3 wherein the aqueous peritoneal dialysis composition contains from 2 to 4% w/v of said glucose polymer mixture.

10. The method of claim 1, 2 or 3 wherein the glucose polymer mixture contains less than 3% by weight of glucose.

11. The method of claim 1, 2 or 3 wherein the aqueous peritoneal dialysis composition contains from 2 to 15% w/v of said glucose polymer mixture.

12. The method of claim 1, 2 or 3 wherein the aqueous peritoneal dialysis composition contains from 2 to 5% w/v of said glucose polymer mixture.

13. The method of claim 1, 2 or 3 wherein the patient suffers from renal failure.

14. The method of claim 1, 2 or 3 wherein the starch contains not more than 5% of 1,6-linkages.
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