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|Title:||Novel dibenzothiazepine antipsychotic|
|Abstract:||11-[4-[2-(2-Hydroxyethoxy)ethyl]-1-piperazinyl]dibenzo[b,f][1,4 ]thiazepine is disclosed as a neuroleptic with a much reduced incidence of side effects such as acute dystonia and dyskinesia and tardive diskinesia.|
|Inventor(s):||Warawa; Edward J. (Wilmington, DE), Migler; Bernard M. (Cherry Hill, NJ)|
|Assignee:||ICI Americas Inc. (Wilmington, DE)|
1. A compound of formula II ##STR14## and acid addition salts thereof.
2. A compound as claimed in claim 1 wherein said acid addition salts are phamaceutically acceptable acid addition salts.
3. A compound as claimed in claim 2 wherein said salt is a hemifumarate salt.
4. A compound as claimed in claim 2 wherein said salt is a hydrochloride salt.
5. A pharmaceutical composition comprising a compound of claim 2 in an amount sufficient to manage a psychotic condition in a living mammal in need of such treatment in association with a non-toxic pharmaceutically acceptable diluent or carrier.
6. A pharmaceutical composition comprising a compound of claim 2 in an amount sufficient to reduce hyperactivity in a living mammal in need of such treatment in association with a non-toxic pharmaceutically acceptable diluent or carrier.
7. A method of treating psychosis in a living mammal comprising administering to the mammal an effective amount of a composition of claim 2.
8. A method of treating hyperactivity in a living mammal comprising administering to the mammal an effective amount of a composition of claim 2.
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