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Claims for Patent: 4,879,288

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Claims for Patent: 4,879,288

Title: Novel dibenzothiazepine antipsychotic
Abstract:11-[4-[2-(2-Hydroxyethoxy)ethyl]-1-piperazinyl]dibenzo[b,f][1,4 ]thiazepine is disclosed as a neuroleptic with a much reduced incidence of side effects such as acute dystonia and dyskinesia and tardive diskinesia.
Inventor(s): Warawa; Edward J. (Wilmington, DE), Migler; Bernard M. (Cherry Hill, NJ)
Assignee: ICI Americas Inc. (Wilmington, DE)
Application Number:07/028,473
Patent Claims: 1. A compound of formula II ##STR14## and acid addition salts thereof.

2. A compound as claimed in claim 1 wherein said acid addition salts are phamaceutically acceptable acid addition salts.

3. A compound as claimed in claim 2 wherein said salt is a hemifumarate salt.

4. A compound as claimed in claim 2 wherein said salt is a hydrochloride salt.

5. A pharmaceutical composition comprising a compound of claim 2 in an amount sufficient to manage a psychotic condition in a living mammal in need of such treatment in association with a non-toxic pharmaceutically acceptable diluent or carrier.

6. A pharmaceutical composition comprising a compound of claim 2 in an amount sufficient to reduce hyperactivity in a living mammal in need of such treatment in association with a non-toxic pharmaceutically acceptable diluent or carrier.

7. A method of treating psychosis in a living mammal comprising administering to the mammal an effective amount of a composition of claim 2.

8. A method of treating hyperactivity in a living mammal comprising administering to the mammal an effective amount of a composition of claim 2.
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