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Claims for Patent: 4,871,865

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Claims for Patent: 4,871,865

Title: Tricyclic aromatic compounds
Abstract:The present invention relates to compounds of formula I ##STR1## or a salt, ester or amide thereof; wherein R.sup.1 is --CH.sub.2 --CH.sub.2 --, CH.sub.2 --O-- or --O--CH.sub.2 --; R.sup.2 and R.sup.3 are the same or different and are each hydrogen, C.sub.1-4 alkyl or taken together with the nitrogen comprise a nitrogen-containing heterocyclic ring having four to six ring members; R.sup.4 is a single bond or a C.sub.1-7 bivalent aliphatic hydrocarbon group and may be joined to the aromatic ring system at the 2,3,8 or 9 positions; n is 0 to 3, and their use as anithistamine and antiasthma agents.
Inventor(s): Lever, Jr.; O. William (Skillman, NJ), Leighton; Harry J. (Chapel Hill, NC)
Assignee: Burroughs Wellcome Co. (Research Triangle Park, NC)
Application Number:06/894,306
Patent Claims: 1. A compound of formula (I) ##STR10## or a pharmacologically and pharmaceutically acceptable salt thereof; wherein R.sup.1 is --CH.sub.2 --O--, R.sup.2 and R.sup.3 are the same or different and are each hydrogen or C.sub.1-4 alkyl, R.sup.4 is a C.sub.1-2 bivalent hydrocarbon group and is joined to the aromatic ring system at the 2 position and n is 2.

2. The compound of claim 1 in which R.sup.2 and R.sup.3 are methyl.

3. The compound of claim 1 which is (z-11-(3-(Dimethylamino)propylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acryl ic acid.
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