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Serving 500+ biopharmaceutical companies globally:

Novartis
Argus Health
Boehringer Ingelheim
Daiichi Sankyo
US Army
Chubb
Deloitte
AstraZeneca
Healthtrust
Queensland Health

Generated: September 26, 2017

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Title: Intravaginal devices
Abstract:The invention concerns an intravaginal device comprising a combination of 17 .beta.-estradiol and a supporting matrix for treating hypoestrogenic women. The device releases continuously 17 .beta.-estradiol at a rate of about 0.5 to about 25 .mu.g/24 h. The invention also comprises a method of preparing the device and a method of treating hypoestrogenic women by using the device.
Inventor(s): Lindskog; Inga M. (Helsingborg, SE), Sjogren; Bengt C. H. (Viken, SE), Andersson; Sven-Borje (Od.ang.kra, SE)
Assignee: Aktiebolaget Leo (Helsingborg, SE)
Application Number:07/060,833
Patent Claims: 1. An intravaginal device for use by hoypoestrogenic women in the form of a ring which consists of a core of a pharmacologically acceptable elastomer and an outer elastomer layer surrounding said core, said core having 17 beta-estradiol homogeneously suspended therein in such a way that the 17 beta-estradiol will be continuously released from the ring at an essentially constant rate of about 0.5 to 25 .mu.g per 24 hours for at least a month.

2. An intravaginal device according to claim 1 wherein the release rate is from about 1 to about 10 .mu.g/24 h.

3. An intravaginal device according to claim 1 wherein the release rate is from about 4 to about 8 .mu.g/24 h.

4. An intravaginal device according to claim 1 wherein said core elastomer is a polydimethylsiloxane and said outer elastomer layer is silicone tubing.

5. A method of treating a woman having symptoms of hypoestrogenicity which comprises positioning within the woman an intravaginal device in the form of a ring which consists of a core of a pharmacologically acceptable elastomer and an outer elastomer layer surrounding said core, said core having 17 beta-estradiol homogeneously suspended therein in such a way that the 17 beta-estradiol will be continuously released from the ring at an essentially constant rate of about 0.5 to 25 .mu.g per 24 hours for at least a month.

6. A method according to claim 5 wherein the release rate is from about 1 to about 10 .mu.g/24 h.

7. A method according to claim 5 wherein the release rate is from about 4 to about 8 .mu.g/24 h.

8. A method according to claim 5 wherein said core elastomer is a polydimethylsiloxane and said outer elastomer layer is silicone tubing.
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Serving 500+ biopharmaceutical companies globally:

Novartis
Mallinckrodt
Daiichi Sankyo
Medtronic
Moodys
Covington
Fuji
Dow
McKinsey
Teva

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

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