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Claims for Patent: 4,868,179

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Claims for Patent: 4,868,179

Title: Method of reducing mortality associated with congestive heart failure using hydralazine and isosorbide dinitrate
Abstract:A method of reducing mortality associated with chronic congestive heart failure in a patient with impaired cardiac function and concomitant reduced exercise tolerance, comprising the oral administration to said patient in need of the same of a combination of (a) between about 75 and about 300 milligrams of hydralazine, per day and (b) between about 40 and about 160 milligrams of isosorbide dinitrate, per day.
Inventor(s): Cohn; Jay N. (Minneapolis, MN)
Assignee:
Application Number:07/041,210
Patent Claims: 1. A method of reducing the incidence of mortality associated with chronic congestive heart failure in a patient with impaired cardiac function and concomitant reduced exercise tolerance, comprising the oral administration to said patient in need of the same of a combination of

(a) between about 75 and about 300 milligrams of hydralazine, or a pharmaceutically acceptable acid addition salt thereof, per day, and

(b) between about 40 and about 160 milligrams of isosorbide dinitrate, per day.

2. A method according to claim 1, wherein said patient is further treated orally with digoxin in an amount sufficient to achieve in said patient a blood serum concentration of digoxin of at least about 0.7 nanograms per milliliter and an effective edema managing amount of a pharmaceutically acceptable diuretic selected from the group consisting of thiazides, ethacrynic acid, furosemide, spironalactone and triamterene.
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