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Claims for Patent: 4,861,760

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Claims for Patent: 4,861,760

Title: Ophthalmological composition of the type which undergoes liquid-gel phase transition
Abstract:The present invention relates to a pharmaceutical composition intended for contacting with a physiological liquid characterized in that said composition is intended to be administered as a non-gelled liquid form and is intended to gel in situ, this composition containing at least one polysaccharide in aqueous solution, of the type which undergoes liquid-gel phase transition gelling in situ under the effect of an increase in the ionic strength of said physiological liquid.
Inventor(s): Mazuel; Claude (Riom, FR), Friteyre; Marie-Claire (Riom, FR)
Assignee: Merck & Co., Inc. (Rahway, NJ)
Application Number:06/911,606
Patent Claims: 1. A liquid aqueous ophthalmological composition comprising 0.1 to 2% by weight of gellan gum which on administration to the eye changes from a liquid to a gel as a result of the ionic strength of the lacrimal fluid.

2. The composition of claim 2 which additionally comprises about 0.001% to 5% by weight of an ophthalmic pharmaceutically-active substance.

3. The composition of claim 2 wherein the pharmaceutically-active substance is selected from the group consisting of an antibacterial substance and an anti-glaucoma drug.

4. The composition of claim 3 wherein the antibacterial substance is norfloxacin and the antiglaucoma drug is timolol maleate or a carbonic anhydrase inhibitor.

5. The composition of claim 1 wherein the gellan gum is Gelrite.

6. The composition of claim 5 which additionally comprises about 0.001% to 5% by weight of an ophthalmic pharmaceutically-active substance.

7. The composition of claim 6 wherein the pharmaceutically-active substance is selected from the group consisting of an antibacterial substance and an antiglaucoma drug.

8. The composition of claim 7 wherein the antibacterial substance is norfloxacin and the antiglaucoma drug is selected from the group consisting of timolol maleate and a carbonic anhydrase inhibitor.
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