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Claims for Patent: 4,857,330

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Claims for Patent: 4,857,330

Title: Chlorpheniramine therapy
Abstract:An osmotic dosage form is disclosed for delivering chlorpheniramine.
Inventor(s): Stephens; Sally I. (Mountain View, CA), Hamel; Lawrence G. (Sunnyvale, CA), Barclay; Glen E. (Sunnyvale, CA), Wong; Patrick S. L. (Hayward, CA)
Assignee: Alza Corporation (Palo Alto, CA)
Application Number:07/176,561
Patent Claims: 1. A dosage for for delivering chlorpheniramine to a biological environment of use, the dosage form comprising:

(a) a wall comprising in at least a part a composition comprising a member selected from the group consisting of a cellulose acylate, a cellulose diacylate and a cellulose triacylate, which wall is permeable to the passage of an exterior fluid, substantially impermeable to the passage of chlorpheniramine, and surrounds and forms:

(b) a compartment;

(c) a composition in the compartment comprising a dosage unit amount of chlorpheniramine and mannitol, with the amount of mannitol and the amount of chlorpheniramine being selected to provide a mannitol concentration of from 1.5 to 6 times greater than the chlorpheniramine; and,

(d) at least one passageway in the wall connecting the compartment with the exterior of the dosage form for dispensing chlorpheniramine at a substantially even rate to the environment of use over time.

2. The dosage form for delivering chlorpheniramine according to claim 1, wherein chlorpheniramine is present as a pharmaceutically acceptable salt.

3. The dosage form for delivering chlorpheniramine according to claim 1, wherein the composition comprises chlorpheniramine present as a pharmaceutically acceptable salt and mannitol.

4. The dosage form for delivering chlorpheniramine according to claim 1, wherein chlorpheniramine is present as chlorpheniramine meleate.

5. The dosage form for delivering chlorpheniramine according to claim 1, wherein the cellulose triacylate is cellulose triacetate.

6. The dosage form for delivering chlorpheniramine according to claim 1, wherein the compartment comprises from 2 to 24 mg of chlorpheniramine.

7. The dosage form for delivering chlorpheniramine according to claim 1, wherein the dosage form comprises an outermost layer comprising chlorpheniramine.

8. The dosage form for delivering chlorpheniramine according to claim 1, wherein the dosage form comprises an outermost layer comprising from 1 to 15 mg of chlorpheniramine.

9. The dosage form for delivering chlorpheniramine according to claim 1, wherein environment of use is the gastrointestinal tract, and the dosage form is adapted for oral admittance into said environment of use.
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