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Claims for Patent: 4,851,229

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Claims for Patent: 4,851,229

Title: Composition comprising a therapeutic agent and a modulating agent
Abstract:An osmotic delivery system is disclosed for delivering a useful agent at a controlled and constant rate modulated by a pulsed delivery of the useful agent to an environment of use.
Inventor(s): Magruder; Paul R. (Palo Alto, CA), Barclay; Brian (Menlo Park, CA), Wong; Patrick S. L. (Hayward, CA), Theeuwes; Felix (Los Altos, CA)
Assignee: ALZA Corporation (Palo Alto, CA)
Application Number:07/150,124
Patent Claims: 1. A composition useful for producing a pulsed rate of delivery of a therapeutic agent from an osmotic device, said composition comprising a therapeutic agent and a modulating agent that dissolves in aqueous fluid and forms a solution, which modulating agent is a different agent than the therapeutic agent, said modulating agent a member selected from the group of modulating agents consisting of a solid organic acid, an inorganic salt, and an organic salt, said modulating agent present relative to said therapeutic agent in an amount less than the amount needed to maintain saturation in aqueous fluid that enters the osmotic device and wets the composition, thereby letting the concentration of the therapeutic agent increase in the aqueous fluid that enters the osmotic device and produce a pulsed rate of delivery of therapeutic agent from the osmotic device.

2. The composition useful for producing a pulsed rate of delivery of a therapeutic agent from an osmotic device according to claim 1, wherein the therapeutic agent is salbutamol.
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