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Claims for Patent: 4,849,228

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Claims for Patent: 4,849,228

Title: Polymer, production and use thereof
Abstract:The present invention provides a biodegradable high molecular polymer characterized in that the content of water-soluble low molecular compounds, as calculated on the assumption that said compounds each is a monobasic acid, is less than 0.01 mole per 100 grams of said high molecular polymer. The thus-obtained high molecular polymer has good aging stability and can be used advantageously as an exipient for pharmaceutical preparations.
Inventor(s): Yamamoto; Masaki (Osaka, JP), Okada; Hiroaki (Osaka, JP), Ogawa; Yasuaki (Osaka, JP), Miyagawa; Tsutomu (Saitama, JP)
Assignee: Takeda Chemical Industries, Ltd. (Osaka, JP)
Application Number:07/117,618
Patent Claims: 1. A microcapsule for injectable sustained release which contains an effective amount of ingredient and a biodegradable high molecular polymer useful as an excipient in producing a pharmaceutical preparation comprising a copolymer or homopolymer of about 50-100 mole percent of lactic acid and about 50-0 mole percent of glycolic acid having a weight average molecular weight of about 2,000 to 50,000 and wherein the content of water-soluble low molecular compounds, as calculated on the assumption that each of said compounds is a monobasic acid, is less than 0.01 mole per 100 grams of said high molecular polymer.

2. The microcapsule according to claim 1, wherein the ingredient is a water-soluble peptide.

3. The microcapsule according to claim 2, wherein the water-soluble peptide has luteinizing hormone releasing hormone-like activity or thyroid hormone releasing hormone-like activity.

4. The microcapsule according to claim 3, wherein the peptide having the luteinizing hormone releasing hormone-like activity has the formula:

5. The microcapsule according to claim 1, wherein the biodegradable high molecular polymer has an inherent viscosity of about 0.05-0.5 dl/g as determined with a 0.5 weight percent chloroform solution thereof and a weight average molecular weight of about 5,000-35,000.
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