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Claims for Patent: 4,837,111

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Claims for Patent: 4,837,111

Title: Dosage form for dispensing drug for human therapy
Abstract:An osmotic dosage system is disclosed for delivering the therapeutically beneficial drug doxazosin to an environment of use over time.
Inventor(s): Deters; Joseph C. (Mountain View, CA), Wong; Patrick S. L. (Hayward, CA), Barclay; Brian L. (Sunnyvale, CA), Theeuwes; Felix (Los Altos, CA), Swanson; David R. (Palo Alto, CA)
Assignee: ALZA Corporation (Palo Alto, CA)
Application Number:07/173,524
Patent Claims: 1. An osmotic device for administering a therapeutically effective amount of doxazosin to an environment of use, the osmotic device comprising:

(a) a wall comprising in at least a part a cellulose acetate composition permeable to the passage of an exterior fluid, which wall surrounds and forms;

(b) a compartment;

(c) a first composition in the compartment, said first composition comprising from 1 to 25 mg of doxazosin, from 250 to 325 mg of polyethylene oxide, and from 10 to 30 mg of hydroxypropylmethylcellulose;

(d) a second composition in the compartment, said second composition comprising from 110 to 140 mg of polyethylene oxide, from 40 to 70 mg of sodium chloride, and from 5 to 25 mg of hydroxypropylmethylcellulose; and,

(e) at least one passageway in the wall communicating with the compartment and the exterior of the device for delivering the therapeutic drug doxazosin to the environment of use.

2. The osmotic device for administering doxazosin according to claim 1, wherein the first composition comprises 2.4 mg of doxazosin mesylate, 83 mg of polyethylene oxide having a 100,000 molecular weight, 56 mg of polyethylene oxide having a 200,000 molecular weight, and 7.5 mg of hydroxypropylmethylcellulose having a 11,300 molecular weight.

3. The osmotic device for administering doxazosin according to claim 1, wherein the first composition comprises 4.8 mg of doxazosin mesylate, 83 mg of polyethylene oxide having a 100,000 molecular weight, 56 mg of polyethylene oxide having a 200,000 molecular weight, and 7.5 mg of hydroxypropylmethylcellulose having a 11,300 molecular weight.

4. The osmotic device for administering doxazosin according to claim 1, wherein the first composition comprises 9.6 mg of doxazosin mesylate, 166 mg of polyethylene oxide having a 100,000 molecular weight, 111 mg of polyethylene oxide having a 200,000 molecular weight and 15 mg of hydroxypropylmethylcellulose having a 11,300 molecular weight.

5. The osmotic device for administering doxazosin according to claim 1, wherein the second composition comprises 64.5 mg of polyethylene oxide having a 7,500,000 molecular weight, 29 mg of sodium chloride, and 5 mg of hydroxypropylmethylcellulose having a 11,300 molecular weight.

6. The osmotic device for administering doxazosin according to claim 1, wherein second composition comprises 129 mg of polyethylene oxide having a 7,500,000 molecular weight, 58 mg of sodium chloride, and 10 mg of hydroxypropylmethylcellulose having a 11,300 molecular weight.

7. The osmotic device for administering doxazosin according to claim 1, wherein the first composition comprises about 2.6 mg of doxazosin mesylate.

8. The osmotic device for administering doxazosin according to claim 1, wherein the first composition comprises about 5.3 mg of doxazosin mesylate.

9. The osmotic device for administering doxazosin according to claim 1, wherein the first composition comprises about 10.6 mg of doxazosin mesylate.

10. The osmotic device for administering doxazosin according to claim 1, wherein the second composition comprises 64.5 mg of polyethylene oxide having a 5,000,000 molecular weight, 29 mg of sodium chloride, and 5 mg of hydroxypropylmethylcellulose having a 11,300 molecular weight.
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