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Claims for Patent: 4,831,031

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Claims for Patent: 4,831,031

Title: Aryl piperazinyl-(C.sub.2 or C.sub.4) alkylene heterocyclic compounds having neuroleptic activity
Abstract:Arylpiperazinyl-ethyl(or butyl)-heterocyclic compounds and their pharmaceutically acceptable acid addition salts are neuroleptic agents. They are useful in the treatment of psychotic disorders.
Inventor(s): Lowe, III; John A. (Stonington, CT), Nagel; Arthur A. (Gales Ferry, CT)
Assignee: Pfizer Inc. (New York, NY)
Application Number:07/146,886
Patent Claims: 1. A compound of the formula ##STR4## or a pharmaceutically acceptable acid addition salt thereof, wherein Ar is benzoisothiazolyl or an oxide or dioxide thereof each optionally substituted by one fluoro, chloro, trifluoromethyl, methoxy, cyano, or nitro;

n is 1 or 2; and

X and Y together with the phenyl to which they are attached form benzothiazolyl; 2-aminobenzothiazolyl; benzoisothiazolyl; indazolyl; 2-hydroxyindazolyl; indolyl; oxindolyl optionally substituted by one to three of (C.sub.1 -C.sub.3)alkyl, or one of chloro, fluoro or phenyl, said phenyl optionally substituted by one chloro or fluoro; benzoxazolyl; 2-aminobenzoxazolyl; benzoxazolonyl; 2-aminobenzoxazolinyl; benzothiazolonyl; bezoimidazolonyl; or benzotriazolyl.

2. A compound according to claim 1 wherein X and Y together with the phenyl to which they are attached form benzoxazolonyl.

3. A compound according to claim 2 wherein Ar is benzoisothiazolyl and n is 1.

4. A compound according to claim 1 wherein X and Y together with the phenyl to which they are attached form oxindole.

5. A pharmaceutical composition having neuroleptic activity comprising a compound according to claim 1 in an amount effective in the treatment of neuroleptic diseases, and a pharmaceutically acceptable carrier.

6. A composition according to claim 5 wherein X and Y together with the phenyl to which they are attached form benzoxazolonyl.

7. A composition according to claim 6 wherein Ar is benzoisothiazolyl and n is 1.

8. A composition according to claim 5 wherein X and Y together with the phenyl to which they are attached form oxindole.

9. A method of treating neuroleptic diseases which comprises administering to a subject in need of treatment a neuroleptic amount of a compound according to claim 1.
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