Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

Serving hundreds of leading biopharmaceutical companies globally:

Accenture
US Department of Justice
Mallinckrodt
AstraZeneca
Chinese Patent Office
Harvard Business School
Dow
Federal Trade Commission
Deloitte

Generated: May 20, 2018

DrugPatentWatch Database Preview

Claims for Patent: 4,830,010

« Back to Dashboard

Summary for Patent: 4,830,010
Title: Methods for the diagnosis of gastrointestinal disorders
Abstract:Methods for the diagnosis of gastrointestinal disorders in human or lower animal subjects comprising the steps of administering to said subject a safe and effective amount of urea and analyzing the breath of said subject for the presence of carbon dioxide or ammonia products of the hydrolysis of said urea, wherein the presence of said hydrolysis products is a positive indication of a gastrointestinal disorder in said subject. Preferably the administered urea contains isotope-labelled nitrogen or carbon.
Inventor(s): Marshall; Barry J. (Mount Hawthorn 6016, Perth, Western Australia, AU)
Assignee:
Application Number:07/147,058
Patent Claims: 1. A method for the diagnosis in a human or lower animal subject of a gastrointestinal disorder of the upper gastrointestinal tract caused or mediated by the bacteria Campylobacter pyloridis, said method comprising the steps of administering to said subject a safe and effective amount of isotope-labeled urea, and analyzing the breath of said subject for the presence of isotope-labeled carbon dioxide, isotope-labeled ammonia, or both hydrolysis products, wherein the presence of either or both said hydrolysis products is a positive indication of said gstrointestinal disorder in said subject.

2. A method for the diagnosis in a human or lower animal subject of a gastrointestinal disorder of the upper gastrointestinal tract caused or mediated by bacteria which result in the gastric materials of the human or lower animal to contain relatively large quantities of urease, said method comprising the steps of administering to said subject a safe and effective amount of isotope-labeled urea, and analyzing the breath of said subject for the presence of isotope-labeled carbon dioxide, isotope-labeled ammonia, or both hydrolysis products, wherein the presence of either or both said hydrolysis products is a positive indication of said gastrointestinal disorder in said subject.

3. A method for the diagnosis of a gastrointestinal disorder of the upper gastrointestinal tract caused or mediated by bacteria resulting in the gastric materials containing relatively large quantities of urease in a human or lower animal subject, according to claim 2 wherein said analyzing step involves analyzing the breath of said subject for the presence of isotope-labeled carbon dioxide hydrolysis product of said isotope-labeled urea.

4. The method for the diagnosis of a gastrointestinal disorder of the upper gastrointestinal tract caused or mediated by bacteria resulting in the gastric materials containing relatively large quantities of urease in a human or lower animal subject, according to claim 3, wherein said urea is isotope-labeled with carbon-14 isotope.

5. A method for the diagnosis of a gastrointestinal disorder of the upper gastrointestinal tract caused or mediated by bacteria resulting in the gastric materials containing relatively large quantities of urease in a human or lower animal subject, according to claim 3, wherein said urea is isotope-labeled with carbon-13 isotope.

6. A method for the diagnosis of a gastrointestinal disorder of the upper gastrointestinal tract caused or mediated by bacteria resulting in the gastric materials containing relatively large quantities of urease in a human or lower animal subject, according to claim 2, wherein said analyzing step involves analyzing the breath of said subject for the presence of isotope-labeled ammonia hydrolysis product of said isotope-labeled urea.

7. A method for the diagnosis of a gastrointestinal disorder of the upper gastrointestinal tract caused or mediated by bacteria resulting in the gastric materials containing relatively large quantities of urease in a human or lower animal subject, according to claim 6, wherein said urea is isotope-labeled with nitrogen-15 isotope.

For more information try a trial or see the plans and pricing

Serving hundreds of leading biopharmaceutical companies globally:

UBS
Argus Health
Julphar
Cantor Fitzgerald
Citi
Fish and Richardson
Mallinckrodt
Cerilliant
AstraZeneca

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.