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Claims for Patent: 4,828,838

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Claims for Patent: 4,828,838

Title: Treatment of human viral infection
Abstract:Treatment of AIDS or humans carrying or infected with the AIDS virus or having antibodies to the AIDS virus is disclosed using the compound 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof. Also disclosed is the use of 5'-mono-, di- and triphosphate of 3'-azido-3'-deoxythymidine or a pharmaceutically acceptable basic salt thereof for the same purpose.
Inventor(s): Rideout; Janet L. (Raleigh, NC), Barry; David W. (Chapel Hill, NC), Lehrman; Sandra N. (Durham, NC), St. Clair; Martha H. (Durham, NC), Furman; Phillip A. (Durham, NC)
Assignee: Burroughs Wellcome Co. (Research Triangle Park, NC)
Application Number:07/111,208
Patent Claims: 1. A pharmaceutical preparation comprising a capsule containing 5 to 500 mg of 3'-azido-3'-deoxythymidine.

2. The capsule according to claim 1 containing 10 to 200 mg of 3'-azido-3'-deoxythymidine.

3. The capsule according to claim 1 containing 20 to 100 mg at 3'-azido-3'-deoxythymidine.

4. A tablet for oral administration containing 5 to 500 mg of 3'-azido-3'-deoxythymidine and a pharmaceutically acceptable solid carrier therefor.

5. A tablet according to claim 4 containing 10 to 200 mg of 3'-azido-3'-deoxythymidine.

6. A tablet according to claim 4 containing 20 to 100 mg of 3'-azido-3'-deoxythymidine.

7. A pharmaceutical preparation comprising a capsule containing 5 to 500 mg of a pharmaceutically acceptable salt of 3'-azido-3'-deoxythymidine.

8. A tablet for oral administration containing 5 to 500 mg of a pharmaceutically acceptable salt of 3'-azido-3'-deoxythymidine.
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