.

Pharmaceutical Business Intelligence

  • Anticipate P&T budget requirements
  • Evaluate market entry opportunities
  • Find generic sources and suppliers
  • Predict branded drug patent expiration

► Plans and Pricing

Upgrade to enjoy subscriber-only features like email alerts and data export. See the Plans and Pricing

DrugPatentWatch Database Preview

Claims for Patent: 4,826,821

« Back to Dashboard

Claims for Patent: 4,826,821

Title: Lung surfactant compositions
Abstract:An improved synthetic lung surfactant consists essentially of dipalmitoyl phosphatidyl choline, a C-14 to C-18 fatty alcohol (preferably hexadecanol), and a non-toxic nonionic surface active agent (preferably tyloxapol). The surfactant is prepared in a powdered lyophilized form that can be stored for extended periods at room temperature. The powdered product can be readily reconstituted by simply adding distilled water.
Inventor(s): Clements; John A. (Tiburon, CA)
Assignee: The Regents of the University of California (Berkeley, CA)
Application Number:06/927,340
Patent Claims: 1. An improved synthetic lung surfactant composition having improved dispersant properties in aqueous suspension, as compared to a lung surfactant composition consisting essentially of dipalmitoyl phosphatidyl choline and a fatty alcohol having from 14 to 18 carbon atoms, which improved surfactant consists essentially of:

(a) dipalmitoyl phosphatidyl choline, which is present in at least 80% by weight of the total weight of the dipalmitoyl phosphatidyl choline and fatty alcohol,

(b) a fatty alcohol having from 14 to 18 carbon atoms, which is present relative to the sum of the weights of the components of dipalmitoyl phosphatidyl choline, fatty alcohol and surface active agent in between about 7 and 10% by weight,

(c) a non-ionic physiologically acceptable non-toxic surface active agent of the alkyl aryl polyether alcohol type of the structure: ##STR3## wherein R=--CH.sub.2 CH.sub.2 O(CH.sub.2 CH.sub.2 O).sub.m CH.sub.2 CH.sub.2 OH;

R'=--C(CH.sub.3).sub.2 CH.sub.2 C(CH.sub.3).sub.2 CH.sub.3 ;

m=6 to 8; and

n=4 or 5, which is present in about 6 to 11 percent by weight of the organic components of the composition; and

(d) sodium chloride present as a minor component by weight.

2. The composition of claim 1 wherein the surface active agent is tyloxapol.

3. The composition of claim 2 wherein the dipalmitoyl phosphatidyl choline is at least 90 percent by weight of the total weight of the dipalmitoyl phosphatidyl choline and fatty alcohol.

4. The composition of claim 1 wherein is suspended in saline solution.

5. A powdered lyophilized lung surfactant composition, having improved dispersant properties in aqueous solution as compared to a lung surfactant composition consisting essentially of dipalmitoyl phosphatidyl choline and a fatty alcohol having from 14 to 18 carbon atoms, which improved surfactant composition consists essentially of dipalmitoyl phosphatidyl choline, a C-14 to C-18 fatty alcohol, a physiologically acceptable non-toxic non-ionic surface active agent of the alkyl aryl polyether alcohol type of the structure: ##STR4## wherein R=--CH.sub.2 CH.sub.2 O(CH.sub.2 CH.sub.2 O).sub.m CH.sub.2 CH.sub.2 OH;

R'=--C(CH.sub.3 .sub.2 CH.sub.2 C(CH.sub.3).sub.2 CH.sub.3 ;

m=6 to 8; and

n=4 or 5; and sodium chloride

wherein the dipalmitoyl phosphatidyl choline is present in at least 80 percent by weight of the total weight of the dipalmitoyl phosphatidyl choline and fatty alcohol, the fatty alcohol is present relative to the sum of the weights of the components of dipalmitoyl phosphatidyl choline, fatty alcohol and surface active agent in between about 9 and 10 percent by weight, the surface active agent is present in about 6 to 11 percent by weight of the sum of the organic components of the compositions, and sodium chloride is a minor component by weight.

6. The surfactant composition of claim 5 wherein the surface active agent is tyloxapol.

7. The compositin of claim 6 wherein the dipalmitoyl phosphatidyl choline is present in at least 90 percent by weight of the total weight of the dipalmitoyl phosphatidyl choline and fatty alcohol.
« Back to Dashboard

For more information try a trial or see the database preview and plans and pricing

How are People Using DrugPatentWatch?

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

`abc