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Claims for Patent: 4,816,263

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Claims for Patent: 4,816,263

Title: Dosage form for treating cardiovascular diseases comprising isradipine
Abstract:An osmotic device is disclosed comprising a first composition, and a second composition with the beneficial drug isradipine in the first composition.
Inventor(s): Ayer; Atul D. (Palo Alto, CA), Swanson; David R. (Palo Alto, CA), Kuczynski; Anthony L. (Palo Alto, CA)
Assignee: ALZA Corporation (Palo Alto, CA)
Application Number:07/104,006
Patent Claims: 1. A method for treating a cardiovascular disease, wherein the method comprises:

(A) admitting into a patient afflicted with a cardiovascular disease an osmotic dosage form comprising:

(1) a wall comprising at least in part a composition permeable to the passage of fluid, which wall surrounds;

(2) a compartment;

(3) a first composition in the compartment, said first composition comprising from 2 milligrams to 30 milligrams of isradipine for treating a cardiovascular disease, from 30 weight percent to 95 weight percent of a polyethylene oxide comprising a molecular weight of from 100,000 to 300,000, and from 0 weight percent to 15 weight percent of a hydroxypropylmethylcellulose comprising a molecular weight of 9,000 to 15,000;

(4) a second composition in the compartment, said second composition comprising from 55 weight percent to 70 weight percent of a polyethylene oxide comprising a molecular weight of from 5,000,000 to 7,800,000, from 15 weight percent to 30 weight percent of an osmotically effective solute, and from 5 weight percent to 15 weight percent of a hydroxypropylmethylcellulose comprising a molecular weight of 9,000 to 20,000 which second composition aid the dosage form in delivering the first composition from the compartment;

(5) at least one passageway in the wall for delivering the isradipine from the dosage form;

(B) letting fluid enter the dosage form for (a) contacting the first composition for providing a dispensable isradipine composition, and for (b) contacting the second composition for causing it to aid in delivering the first composition; thereby,

(C) delivering through the combined operations of the first and second composition a therapeutically effective amount of isradipine to the patient for treating the cardiovascular disease.

2. The method for treating the cardiovascular disease according to claim 1, wherein the cardiovascular disease is angina pectoris.

3. The method for treating the cardiovascular disease according to claim 1, wherein the cardiovascular disease comprises hypertension.

4. The method for treating the cardiovascular disease according to claim 1, wherein the cardiovascular disease comprises congestive heart failure.

5. The method for treating the cardiovascular disease according to claim 1, wherein the dosage form delivers a therapeutically effective amount of from 0.05 mg to 2.5 mg per hour of isradipine.
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