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Claims for Patent: 4,810,502

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Claims for Patent: 4,810,502

Title: Pseudoephedrine brompheniramine therapy
Abstract:A dosage form is disclosed for delivering the beneficial drugs pseudoephedrine and brompheniramine to a biological environment of use.
Inventor(s): Ayer; Atul D. (Mt. View, CA), Hamel; Lawrence G. (Sunnyvale, CA)
Assignee: ALZA Corporation (Palo Alto, CA)
Application Number:07/019,989
Patent Claims: 1. An improvement in a dosage form for delivering the beneficial drugs pseudoephedrine and brompheniramine to an environment of use, the dosage form comprising:

(a) a dosage amount of the beneficial drug pseudoephedrine;

(b) a dosage amount of the beneficial drug brompheniramine;

(c) a wall surrounding the pseudoephedrine and the brompheniramine, the wall comprising a cellulose acylate and hydroxypropylcellulose;

(d) at least one passageway in the wall for delivering the pseudoephedrine and the brompheniramine from the dosage form; and,

(e) a lamina in laminar arrangement with the exterior of the wall, the lamina comprising pseudoephedrine, brompheniramine, and at least one member selected from the group consisting of hydroxypropylcellulose and hydroxypropylmethylcellulose, the improvement comprising polyethylene oxide present in the lamina for enhancing the lamina's mechanical integrity and its drug releasing pharmacokinetics.

2. The improved dosage form for delivering the beneficial drugs pseudoephedrine and brompheniramine according to claim 1, wherein the cellulose acylate is cellulose triacetate.

3. The improved dosage form for delivering the beneficial drugs pseudoephedrine and brompheniramine according to claim 1, wherein the psuedoephedrine is a pharmaceutically acceptable salt.

4. The improved dosage form for delivering the beneficial drugs pseudoephedrine and brompheniramine according to claim 1, wherein the brompheniramine is a pharmaceutically acceptable salt.

5. An improvement in a dosage form for delivering the beneficial drugs pseudoephedrine and brompheniramine to an environment of use, the dosage form comprising:

(a) a dosage amount of the beneficial drug pseudoephedrine;

(b) a dosage amount of the beneficial drug brompheniramine;

(c) a wall surrounding the pseudoephedrine and the brompheniramine, the wall comprising a cellulose acylate and hydroxypropylcellulose;

(d) at least one passageway in the wall for delivering the pseudoephedrine and the brompheniramine from the dosage form; and,

(e) a lamina in laminar arrangement with the exterior surface of the wall, the lamina comprising pseudoephedrine, brompheniramine, and at least one member selected from the group consisting of hydroxypropylcellulose and hydroxypropylmethylcellulose, and wherein the improvement comprises carboxyvinyl polymer present in the lamina for enhancing the lamina's mechanical integrity and pharmacokinetics properties of the dosage form.

6. The improved dosage form for delivering the beneficial drugs pseudoephedrine and brompheniramine to the environment of use according to claim 5, wherein the cellulose acylate is cellulose triacetate.

7. The improved dosage form for delivering the beneficial drugs pseudoephedrine and brompheniramine to the environment of use according to claim 5, wherein the pseudoephedrine is present as its pharmaceutically acceptable salt.

8. The improved dosage form for delivering the beneficial drugs pseudoephedrine and brompheniramine to the environment of use according to claim 5, wherein the brompheniramine is present as its pharmaceutically acceptable salt.
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