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Claims for Patent: 4,808,716

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Claims for Patent: 4,808,716

Title: 9-(phosponylmethoxyalkyl) adenines, the method of preparation and utilization thereof
Abstract:The invention relates to 9-(phosphonylmethoxyalkyl)adenines of the general formula I ##STR1## wherein R.sup.1 is a hydrogen atom, and alkyl group containing one to three carbon atoms, or a hydroxymethyl group, R.sup.2 is a methylene, ethylene, propylene, ethylidene, methoxyethylene, benzyloxyethylene, tetrahydropyran-2-yloxyethylene, (1-ethoxyethoxy)ethylene or 1,2-O-isopropylidene-1,2-dihydroxypropylene group the method of their preparation and utilization. Compounds of the general formula I exhibit biological effects (e.g. antiviral) or can be converted into compounds with such effects.
Inventor(s): Holy; Antonin (Praha, CS), Rosenberg; Ivan (Praha, CS)
Assignee: Ceskoslovenska akademic ved (CS)
Application Number:06/856,299
Patent Claims: 1. A 9-(phosphonylmethoxyalkyl)adenine having the formula I ##STR10## wherein R.sup.1 is hydrogen and R.sup.2 is selected from the group consisting of methylene, ethylene, propylene, ethylidene, and 1,2-O-isopropylidene-1,2-di-hydroxypropylene; and the salts thereof with alkali metals or ammonia.

2. A 9-(phosphonylmethoxyalkyl)adenine of the formula ##STR11## wherein R.sup.1 is selected from the group consisting of methyl and hydroxymethyl and R.sup.2 is selected from the group consisting of methylene, ethylene, propylene, ethylidene, methoxyethylene, benzyloxyethylene, tetrahydropyranyl-2-oxyethylene, (1-ethoxyethoxy)ethylene and 1,2-O-isopropylidene-1,2-dihydroxypropylene; and the salts thereof with alkali metals or ammonia.
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