Generated: April 24, 2017
|Title:||9-(phosponylmethoxyalkyl) adenines, the method of preparation and utilization thereof|
|Abstract:||The invention relates to 9-(phosphonylmethoxyalkyl)adenines of the general formula I ##STR1## wherein R.sup.1 is a hydrogen atom, and alkyl group containing one to three carbon atoms, or a hydroxymethyl group, R.sup.2 is a methylene, ethylene, propylene, ethylidene, methoxyethylene, benzyloxyethylene, tetrahydropyran-2-yloxyethylene, (1-ethoxyethoxy)ethylene or 1,2-O-isopropylidene-1,2-dihydroxypropylene group the method of their preparation and utilization. Compounds of the general formula I exhibit biological effects (e.g. antiviral) or can be converted into compounds with such effects.|
|Inventor(s):||Holy; Antonin (Praha, CS), Rosenberg; Ivan (Praha, CS)|
|Assignee:||Ceskoslovenska akademic ved (CS)|
1. A 9-(phosphonylmethoxyalkyl)adenine having the formula I ##STR10## wherein R.sup.1 is hydrogen and R.sup.2 is selected from the group consisting of methylene, ethylene,
propylene, ethylidene, and 1,2-O-isopropylidene-1,2-di-hydroxypropylene; and the salts thereof with alkali metals or ammonia.
2. A 9-(phosphonylmethoxyalkyl)adenine of the formula ##STR11## wherein R.sup.1 is selected from the group consisting of methyl and hydroxymethyl and R.sup.2 is selected from the group consisting of methylene, ethylene, propylene, ethylidene, methoxyethylene, benzyloxyethylene, tetrahydropyranyl-2-oxyethylene, (1-ethoxyethoxy)ethylene and 1,2-O-isopropylidene-1,2-dihydroxypropylene; and the salts thereof with alkali metals or ammonia.
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.