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Serving hundreds of leading biopharmaceutical companies globally:

Daiichi Sankyo
Chinese Patent Office
Farmers Insurance

Generated: June 19, 2018

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Claims for Patent: 4,808,583

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Summary for Patent: 4,808,583
Title: Solutions of lactic acid salts of piperazinylquinolone- and piperazinyl-azaquinolone-carboxylic acids
Abstract:The invention relates to solutions of piperazinylquinolone- and piperazinyl-azaquinolone-carboxylic acids, and in particular both ready-to-use injection and/or infusion solutions and dosage forms which can be converted into such injection and/or infusion solutions before use. The solutions according to the invention are characterized in that, besides the lactic acid salts of the active substance and, if appropriate, customary auxiliaries, they additionally contain at least one acid which does not lead to precipitates, in particular lactic acid.
Inventor(s): Grohe; Klaus (Odenthal, DE), Lammens; Robert (Leverkusen, DE)
Assignee: Bayer Aktiengesellschaft (Leverkusen, DE)
Application Number:07/071,459
Patent Claims: 1. An aqueous storage stable solution which can be converted into an injection or diffusion solution consisting essentially of (a) a lactic acid salt of a piperazinylquinolone- or piperazinyl-azaquinolone-carboxylic acid of the formula ##STR2## in which X denotes N, C--H or C--F,

R.sub.1 denotes hydrogen, methyl, ethyl or .beta.-hydroxyethyl,

R.sub.2 denotes cyclopropyl or ethyl and

R.sub.3 denotes hydrogen, methyl or ethyl, and (b) and excess acid selected from the group consisting of methanesulphonic acid, propionic acid, succinic acid and hydrochloric acid, the excess acid being present in an amount which does not lead to precipitates and constituting about 0.01 to 90% based on the solution.

2. A solution according to claim 1, which contains the lactate of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-car boxylic acid.

3. A solution according to claim 1, which contains the lactate of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxyli c acid.

4. A solution according to claim 1, which contains the lactate of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-c arboxylic acid.

5. A solution according to claim 1 in which the content of excess acid is 0.01 to 25%.

6. A solution according to claim 1, in which the content of excess acid is 0.025 to 1.4%.

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Serving hundreds of leading biopharmaceutical companies globally:

Boehringer Ingelheim
US Department of Justice
Queensland Health
Chinese Patent Office

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