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Claims for Patent: 4,800,079

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Claims for Patent: 4,800,079

Title: Medicine based on fenofibrate, and a method of preparing it
Abstract:A granular medicine based on fenofibrate, each granule comprising an inert core, a layer based on fenofibrate, and a protective layer, the medicine being characterized in that the fenofibrate in the layer based on fenofibrate is present in the form of crystalline microparticles of dimensions not greater than 30 microns, and preferably less than 10 microns.
Inventor(s): Boyer; Jean-Francois (78550 Houdan, FR)
Assignee:
Application Number:07/083,409
Patent Claims: 1. Medicine in the form of granules with controlled release of fenofibrate, each granule comprising an inert core, a layer based on fenofibrate and a protective layer, wherein the improvement comprises the layer based on fenofibrate containing the fenofibrate in the form of crystalline microparticles of dimensions not greater than 30 microns, said microparticles being included in the pores of an inert matrix soluble in water.

2. A medicine according to claim 1, wherein the inert matrix is composed by a binder selected from the group comprising: methacrylic polymers, polyvinylpyrolidone, mixtures thereof; cellulose derivatives; and polyethylene glycols.

3. A medicine according to claim 1, wherein the inert core has a diameter of about 0.3 mm to about 0.6 mm and is constituted by a substance selected from the group comprising: glucose, sucrose, lactose, and their equivalents, and starch, and mixtures thereof.

4. A medicine according to claim 1, wherein the protective layer represents about 1% by weight of each granule, and is formed of a substance selected from the group comprising: methacrylic polymers, polyvinylpyrolidone, mixtures thereof; cellulose derivatives; and polyethylene glycols.

5. A medicine according to claim 1, wherein the quantity of binder is such that the quantity of fenofibrate liberated in one hour in an aqueous liquid is not less than 65%.

6. Medicine according to claim 1 wherein the dimensions of said microparticles are less than 10 microns.

7. Medicine according to claim 3 wherein the starch is maize starch.
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