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Claims for Patent: 4,794,106

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Claims for Patent: 4,794,106

Title: Cream
Abstract:An oil-in-water type cream comprising (a) 0.01 to 0.5% by weight of hydrocortisone butyrate proponate, (b) 5 to 50% by weight of a higher paraffinic hydrocarbon, (c) 3 to 15% by weight of a surface-active agent, (d) 30 to 65% by weight of purified water, (e) not more than 20% by weight of a monohydric higher alcohol, (f) not more than 20% by weight of a dihdyric or trihydric alcohol, and (g) a pharmaceutically acceptable acid in an amount required to adjust the pH of the cream to a value in the range of 3.5 to 6.5 when it is diluted with water to 20 times its volume.
Inventor(s): Takashima; Yasuji (Saitama, JP), Tanaka; Shigeo (Saitama, JP), Tsunoda; Kenji (Saitama, JP), Kawamata; Ichirou (Saitama, JP), Murayama; Hiroshi (Tokyo, JP)
Assignee: Taisho Pharmaceutical Co., Ltd. (Tokyo, JP)
Application Number:06/902,002
Patent Claims: 1. An oil-in-water type cream for topical application consisting essentially of:

(a) 0.01 to 0.5% by weight of hydrocortisone butyrate propionate,

(b) 5 to 50% by weight of a higher paraffinic hydrocarbon component selected from the group consisting of light liquid paraffin, liquid paraffin, white petrolatum, yellow petrolatum, paraffin, ceresin and a mixture thereof,

(c) 3 to 15% by weight of a surface-active agent component having a total HLB of 9 to 12 consisting of a member selected from the group consisting of a sorbitan fatty acid ester, a glycerin fatty acid ester, a propylene glycol fatty acid ester, and a mixture thereof, said surface-active agent component being the only surface-active agent component in the cream,

(d) 30 to 65% by weight of purified water,

(e) 5 to 15% by weight of a monohydric higher alcohol component selected from the group consisting of cetyl alcohol, stearyl alcohol, cetostearyl alcohol, myristyl alcohol and a mixture thereof,

(f) 5 to 15% by weight of a member selected from the group consisting of a glycol having 2 to 6 carbon atoms and glycerol, and

(g) a pharmaceutically acceptable acid selected from the group consisting of citric acid, lactic acid, phosphoric acid, tartaric acid, malic acid and maleic acid in an amount required to adjust the pH of the cream to a value in the range of 3.5 to 6.5 when it is diluted with distilled water to 20 times its volume.

2. The cream of claim 1 wherein the higher paraffinic hydrocarbon component has a viscosity of 10 to 10.sup.6 centipoises at 20.degree. C.

3. The cream of claim 1 which contains the higher paraffinic hydrocarbon component in a concentration of 15 to 40% by weight.

4. The cream of claim 1 which contains the surface-active agent component in a concentration of 4 to 10% by weight.

5. The cream of claim 1 which contains purified water in a concentration of 40 to 55% by weight.

6. The cream of claim 1 wherein the amount of the pharmaceutically acceptable acid is one required to adjust the pH of the cream to 4.0 to 6.0 when it is diluted with distilled water to 20 times its volume.

7. The cream of claim 1 wherein the pharmaceutically acceptable acid is citric acid.

8. The cream of claim 1 wherein the amount of the pharmaceutically acceptable acid is one required to adjust the pH of the cream to 4.5 to 5.5 when it is diluted with distilled water to 20 times its volume.

9. The cream of claim 1 wherein the sorbitan fatty acid ester is a polyoxyethylene sorbitan fatty acid ester.
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