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Claims for Patent: 4,775,529

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Claims for Patent: 4,775,529

Title: Steroid lotion
Abstract:An improved lotion formulation for the topical administration of corticosteroids in a hydro-alcoholic base containing propylene glycol.
Inventor(s): Sequeira; Joel A. (New York, NY), Munayyer; Farah J. (West Caldwell, NJ), Galeos; Rebecca (Bloomfield, NJ)
Assignee: Schering Corporation (Kenilworth, NJ)
Application Number:07/053,172
Patent Claims: 1. A topical lotion for the treatment of inflammation which comprises an amount effect to treat said inflammation of a dermatologically acceptable anti-inflammatory corticosteroid in a hydro-alcoholic base consisting essentially of:

15 to 50% by weight of propylene glycol;

20 to 40% by weight of isopropyl alcohol;

20 to 60% by weight water;

0.1 to 3.0% by weight of a thickening agent, and sufficient buffer to maintain the pH of the composition within the range of 3.0 to 6.0.

2. The lotion of claim 1 wherein the corticosteroid comprises 0.01 to 1.0% by weight of the composition.

3. The lotion of claim 2 wherein the corticosteroid comprises 0.02 to 0.2% by weight of the composition.

4. The lotion of claim 1 wherein the corticosteroid is betamethasone 17,21-dipropionate.

5. The lotion of claim 4 wherein the betamethasone 17,21-dipropionate is present in an amount of 0.064% by weight.

6. The lotion of claim 5 consisting essentially of:

7. The lotion of claim 1 wherein the corticosteroid is alclometasone dipropionate.

8. The lotion of claim 7 consisting essentially of:

9. The lotion of claim 1 wherein the corticosteroid is mometasone furoate.

10. The lotion of claim 9 consisting essentially of:

11. The lotion of claim 1 wherein the thickening agent is an acrylic acid polymer.

12. The lotion of claim 1 wherein the thickening agent is hydroxypropyl cellulose.

13. The method of treating inflammation which comprises applying to the skin a topical lotion formulation comprising an amount effective to treat said inflammation of a dermatologically acceptable anti-inflamatory corticosteroid in a hydro-alcoholic base consisting essentially of:

15 to 50% by weight of propylene glycol;

20 to 40% by weight of isopropyl alcohol;

20to 60% by weight water;

0.1 to 3.0% by weight of a thickening agent, and sufficient buffer to maintain the pH of the composition within the range of 3.0 to 6.0.

14. The method of claim 13 wherein the corticosteroid comprises 0.01 to 1.0% by weight of the composition.

15. The method of claim 14 wherein the corticosteroid comprises 0.02 to 0.2% by weight of the composition.

16. The method of claim 13 wherein the corticosteroid is betamethasone 17,21-dipropionate.

17. The method of claim 13 wherein the corticosteroid is alclometasone dipropionate.

18. The method of claim 13 wherein the corticosteroid is mometasone furoate.
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