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|Title:||Peritoneal dialysis solution containing carbohydrate polymers|
|Abstract:||A peritoneal dialysis solution which comprises a water solution of physiological pH, and having physiological salts and metabolizable carbohydrate polymers in concentrations sufficient to safely effect the removal of solutes and water from a patient by peritoneal dialysis.|
|Inventor(s):||Alexander; Steven R. (Tigard, OR), Myers; W. Michael (Tualatin, OR)|
|Assignee:||Baxter Travenol Laboratories, Inc. (Deerfield, IL)|
1. A method of performing peritoneal dialysis comprising the steps of
(a) introducing into the peritoneal cavity of a patient a solution containing physiological salts in concentrations sufficient to effect the removal of solutes by diffusion from the patient's blood across the peritoneal membrane into the solution, and
(b) reducing the rate of decrease of osmotic pressure with respect to time sufficient to maintain a desired rate of ultrafiltration, by introducing in the solution nonionic starch hydrolyzate glucose polymers in concentrations sufficient to create an osmotic pressure to effect the removal of water by diffusion from the patient's blood across the peritoneal membrane into the solution, the nonionic hydrolyzate glucose polymers having an average degree of polymerization of at least 4 to sustain the osmotic pressure over time due to the relatively slow removal of the polymers by diffusion from the solution across the peritoneal membrane into the patient's blood, when compared to the removal of glucose polymers having an average degree of polymerization less than 4.
2. A method of performing peritoneal dialysis according to claim 1 and further including in said step (b) the introduction of glucose in combination with the nonionic starch hydrolyzate glucose polymers.
3. A method of performing peritoneal dialysis according to claim 1 or 2 wherein, in said step (b), the concentration of the nonionic starch hydrolyzate glucose polymers is sufficient to create an osmolarity of about 272 to about 700 milliosmols per liter of the solution.
4. A method of performing peritoneal dialysis according to claim 3, wherein, in said step (b), the osmolarity created is about 279 to about 480 milliosmols per liter of the solution.
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